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    acs arcus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acsprovided by FlyBase
    Official Full Name
    arcusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035300
    Locus tag
    Dmel_CG1139
    See related
    AllianceGenome:FB:FBgn0035300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1139; Dmel\CG1139
    Summary
    Enables amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport and regulation of growth. Located in basal labyrinth; organelle membrane; and plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See acs in Genome Data Viewer
    Location:
    62B12-62B12; 3-1.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1971638..1974285)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1971638..1974285)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44535

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. Ögmundsdóttir MH, et al. PLoS One, 2012. PMID 22574197, Free PMC Article
    2. Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Newton H, et al. Nat Commun, 2020 Sep 16. PMID 32938923, Free PMC Article
    3. Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter. Socha C, et al. iScience, 2023 Sep 15. PMID 37636057, Free PMC Article
    4. PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Goberdhan DC, et al. Development, 2005 May. PMID 15843412
    5. Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila. Mossman JA, et al. Genetics, 2016 Oct. PMID 27558138, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal labyrinth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arcus
    Names
    CG1139-PA
    acs-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1971638..1974285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139429.2 → NP_647686.1  arcus [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W056
      Related
      FBpp0072724
      Conserved Domains (2) summary
      COG0814
      Location:36 → 404
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:42 → 444
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W056.1 Q9W056

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