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    botv brother of tout-velu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37198, updated on 27-Dec-2024

    Summary

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    Official Symbol
    botvprovided by FlyBase
    Official Full Name
    brother of tout-veluprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027535
    Locus tag
    Dmel_CG15110
    See related
    AllianceGenome:FB:FBgn0027535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21192; Botv; CG15110; dExt3; DExt3; DEXT3; Dextl3; DEXTL3; Dmel\CG15110; Extl3; EXTL3
    Summary
    Enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparan sulfate proteoglycan metabolic process; and heparin biosynthetic process. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including ganglia; head; head mesoderm; trunk mesoderm; and trunk visceral muscle primordium. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See botv in Genome Data Viewer
    Location:
    56B5-56B5; 2-88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19129589..19133706)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15017094..15021211)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1A Neighboring gene Ionotropic receptor 56a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of novel alleles of brother of tout-velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovo(D) chromosome. Lujan E, et al. Genesis, 2016 Nov. PMID 27636555, Free PMC Article
    2. Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. Kim BT, et al. J Biol Chem, 2002 Apr 19. PMID 11832488
    3. Heparan sulfate polymerization in Drosophila. Izumikawa T, et al. J Biol Chem, 2006 Jan 27. PMID 16303756
    4. Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. He BZ, et al. Genetics, 2014 Feb. PMID 24281155, Free PMC Article
    5. Heparan sulfate proteoglycans regulate autophagy in Drosophila. Reynolds-Peterson CE, et al. Autophagy, 2017 Aug 3. PMID 28402693, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. To establish the developmental relevance of this reagent we characterized the maternal-effect phenotypes of novel brother of tout-velu alleles generated on an FRT42D chromosome in a somatic mosaic screen. We find that an apparent null mutation that causes severe defects in somatic tissues has a much milder effect on embryonic patterning, emphasizing the necessity of analyzing mutant phenotypes at multiple developmental st
      Title: Analysis of novel alleles of brother of tout-velu, the drosophila ortholog of human EXTL3 using a newly developed FRT42D ovo(D) chromosome.
    2. Results suggest that all three Drosophila EXT proteins -- tout-velu, brother of tout-velu, and sister of tout-velu -- are required for the biosynthesis of heparan sulfate proteoglycans, and for the gradient formation of morphogens.
      Title: Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.
    3. Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.
      Title: Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brother of tout-velu
    Names
    CG15110-PA
    botv-PA
    brother of tout velu
    brother of tout-velo
    brother of ttv
    brother-of-tout-velu
    drosophila Ext-like 3
    NP_523790.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19129589..19133706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079066.3 → NP_523790.1  brother of tout-velu [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZ08
      Related
      FBpp0085763
      Conserved Domains (3) summary
      pfam03016
      Location:224 → 551
      Exostosin; Exostosin family
      pfam07106
      Location:107 → 185
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam09258
      Location:714 → 949
      Glyco_transf_64; Glycosyl transferase family 64 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ08.1 Q9XZ08

    Gene LinkOut

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