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    Rlip Ral interacting protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42484, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rlipprovided by FlyBase
    Official Full Name
    Ral interacting proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026056
    Locus tag
    Dmel_CG11622
    See related
    AllianceGenome:FB:FBgn0026056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11622; D-RLIP; Dmel\CG11622; dRalBP; dRlip; dRLIP; DRLIP; RalBP1; RhoGAP-93B3; RLIP; RLIP1
    Summary
    Enables small GTPase binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rlip in Genome Data Viewer
    Location:
    93B4-93B4; 3-70 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21017684..21020753)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16843406..16846475)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Na/Ca-exchange protein Neighboring gene Alkaline phosphatase 5 Neighboring gene uncharacterized protein Neighboring gene pegasus Neighboring gene Dynein heavy chain at 93AB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and expression of Ima, a novel Ral-interacting Drosophila protein. Beller M, et al. Mech Dev, 2002 Dec. PMID 14516694
    2. RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Jullien-Flores V, et al. J Cell Sci, 2000 Aug. PMID 10910768
    3. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Johansson J, et al. Cell Stem Cell, 2019 Apr 4. PMID 30853556, Free PMC Article
    4. Novel guanine nucleotide exchange factor GEFmeso of Drosophila melanogaster interacts with Ral and Rho GTPase Cdc42. Blanke S, et al. FASEB J, 2006 Apr. PMID 16581976
    5. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. Rossé C, et al. J Biol Chem, 2003 Aug 15. PMID 12775724

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ral interacting protein
    Names
    CG11622-PA
    CG11622-PB
    Rlip-PA
    Rlip-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21017684..21020753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142676.4 → NP_650933.2  Ral interacting protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650933.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96392, Q8MZ58, Q9VDG2
      Related
      FBpp0083406
      Conserved Domains (1) summary
      cd04381
      Location:187 → 368
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...

    2. NM_001275863.1 → NP_001262792.1  Ral interacting protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHU1
      Conserved Domains (1) summary
      cd04381
      Location:186 → 367
      RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHU1 A0A0B4KHU1
    Q9VDG2.1 Q9VDG2

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