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    miple2 midkine and pleiotrophin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    miple2provided by FlyBase
    Official Full Name
    midkine and pleiotrophin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029002
    Locus tag
    Dmel_CG18321
    See related
    AllianceGenome:FB:FBgn0029002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18321; Dmel\CG18321; Miple2
    Summary
    Enables heparin binding activity. Involved in determination of adult lifespan. Located in extracellular region. Is expressed in several structures, including embryonic/larval midgut primordium; germ layer; gut section; imaginal disc; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See miple2 in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (271200..275018)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (271200..275018)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 1 Neighboring gene uncharacterized protein Neighboring gene tiny tim 2 Neighboring gene Rho guanine nucleotide exchange factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution. Svensson SL, et al. J Biol Chem, 2010 May 21. PMID 20308059, Free PMC Article
    2. The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. Hugosson F, et al. PLoS One, 2014. PMID 25380037, Free PMC Article
    3. Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus. González-Castillo C, et al. Front Cell Neurosci, 2014. PMID 25620911, Free PMC Article
    4. Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster. Englund C, et al. Dev Genes Evol, 2006 Jan. PMID 16220264
    5. Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm. Wolfstetter G, et al. Mech Dev, 2009 Aug-Sep. PMID 19463947

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that Alk is not activated by MDK/PTN related growth factors Miple1 and Miple2 in vivo.
      Title: The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.
    2. Strongly expressed in the developing midgut endoderm.
      Title: Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    midkine and pleiotrophin 2
    Names
    CG18321-PA
    CG18321-PD
    CG18321-PE
    CG18321-PF
    CG18321-PG
    Miple2
    miple2-PA
    miple2-PD
    miple2-PE
    miple2-PF
    miple2-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      271200..275018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274272.1 → NP_001261201.1  midkine and pleiotrophin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Conserved Domains (1) summary
      pfam01091
      Location:156 → 201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

    2. NM_001274269.1 → NP_001261198.1  midkine and pleiotrophin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261198.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDI0, Q9U3W4
      Conserved Domains (1) summary
      pfam01091
      Location:156 → 201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

    3. NM_001274270.1 → NP_001261199.1  midkine and pleiotrophin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE21, Q9U3W4
      Conserved Domains (1) summary
      pfam01091
      Location:156 → 201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

    4. NM_143739.3 → NP_651996.2  midkine and pleiotrophin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651996.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Related
      FBpp0072406
      Conserved Domains (1) summary
      pfam01091
      Location:156 → 201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain

    5. NM_001274271.1 → NP_001261200.1  midkine and pleiotrophin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3W4, Q9W0S4
      Conserved Domains (1) summary
      pfam01091
      Location:156 → 201
      PTN_MK_C; PTN/MK heparin-binding protein family, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDI0 M9PDI0
    M9PE21 M9PE21
    Q8SZ83 Q8SZ83
    Q9U3W4 Q9U3W4
    Q9W0S4 Q9W0S4

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