U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Z600 Z600 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39673, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Z600provided by FlyBase
    Official Full Name
    Z600provided by FlyBase
    Primary source
    FLYBASE:FBgn0004052
    Locus tag
    Dmel_CG17962
    See related
    AllianceGenome:FB:FBgn0004052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3.2; CG17962; Dmel\CG17962; DMZ60MEX; frs; Frs; z600
    Summary
    Enables cyclin binding activity. Involved in negative regulation of G2/M transition of mitotic cell cycle; negative regulation of mitotic nuclear division; and ventral furrow formation. Located in cytoplasm. Is expressed in amnioserosa anlage; amnioserosa primordium; dorsal ectoderm; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Z600 in Genome Data Viewer
    Location:
    71D3-71D3; 3-43 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15509061..15509513)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15502161..15502613)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gdl-ORF39 Neighboring gene gonadal Neighboring gene Methionine sulfoxide reductase A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Frühstart at the midblastula transition. Packer A. Nat Genet, 2003 Oct. PMID 14517537
    2. The Drosophila melanogaster z600 gene encodes a chromatin-associated protein synthesized in the syncytial blastoderm. Galewsky S, et al. Gene, 1990 Dec 15. PMID 2125289
    3. Histone concentration regulates the cell cycle and transcription in early development. Chari S, et al. Development, 2019 Oct 4. PMID 31511251, Free PMC Article
    4. Diverse expression of overlapping genes: the Drosophila Eip28/29 gene and its upstream neighbors. Schulz RA, et al. Dev Biol, 1989 Feb. PMID 2463947
    5. Braking proliferation. Greaves S. Nat Cell Biol, 2000 Jul. PMID 10878821

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dFMRP and Caprin collaborate to control the cell cycle at the MBT by directly mediating the normal repression of maternal Cyclin B mRNA and the activation of zygotic fruhstart mRNA.
      Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
    2. Study show that in Drosophila the mitotic inhibitor Fruhstart (Frs) binds specifically and with high affinity to the hydrophobic patch of cyclins.
      Title: The Drosophila mitotic inhibitor Frühstart specifically binds to the hydrophobic patch of cyclins.
    3. Data show that fruhstart is involved in pausing the cleavage cell cycle in the fertilized egg.
      Title: Control of cleavage cycles in Drosophila embryos by frühstart.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gastrulation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic nuclear division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic nuclear division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ventral furrow formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Z600
    Names
    CG17962-PA
    Z600-PA
    fruhstart
    frustart

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15509061..15509513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079359.4 → NP_524083.2  Z600 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524083.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0JQ32, P22469, Q4V3M0, Q9VUP1
      Related
      FBpp0075304
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22469.2 P22469

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools