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    c12.2 c12.2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53434, updated on 27-Dec-2024

    Summary

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    Official Symbol
    c12.2provided by FlyBase
    Official Full Name
    c12.2provided by FlyBase
    Primary source
    FLYBASE:FBgn0040234
    Locus tag
    Dmel_CG12149
    See related
    AllianceGenome:FB:FBgn0040234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12149; Dmel\CG12149
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to human VWA8 (von Willebrand factor A domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See c12.2 in Genome Data Viewer
    Location:
    8D7-8D7; 1-27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9319359..9324458)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9213392..9218491)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46533 Neighboring gene c12.1 Neighboring gene Zinc finger DHHC-type containing 8 Neighboring gene uncharacterized protein Neighboring gene BCL7-like Neighboring gene Megalin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Dnmt2-like protein mediates DNA methylation in Drosophila. Kunert N, et al. Development, 2003 Nov. PMID 12944428
    2. Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development. Jackson Behan K, et al. Dev Genes Evol, 2005 Aug. PMID 15868204
    3. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    c12.2
    Names
    CG12149-PA
    CG12149-PB
    c12.2-PA
    c12.2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9319359..9324458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272452.1 → NP_001259381.1  c12.2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHH0
      Conserved Domains (2) summary
      cd01455
      Location:1212 → 1403
      vWA_F11C1-5a_type; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam07728
      Location:112 → 268
      AAA_5; AAA domain (dynein-related subfamily)

    2. NM_144347.3 → NP_652604.2  c12.2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652604.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W347
      Related
      FBpp0071256
      Conserved Domains (2) summary
      cd01455
      Location:1195 → 1386
      vWA_F11C1-5a_type; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam07728
      Location:95 → 251
      AAA_5; AAA domain (dynein-related subfamily)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHH0 M9PHH0
    Q9NHX8 Q9NHX8
    Q9W347 Q9W347

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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