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    Mtmr3 myotubularin related protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305482, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtmr3provided by RGD
    Official Full Name
    myotubularin related protein 3provided by RGD
    Primary source
    RGD:1310972
    See related
    EnsemblRapid:ENSRNOG00000007120 AllianceGenome:RGD:1310972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity; phosphatase activity; and protein phosphatase binding activity. Predicted to be involved in several processes, including midbody abscission; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 209.4), Adrenal (RPKM 205.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mtmr3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83564065..83684573, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79340523..79460947, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84701559..84820487, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HORMA domain containing 2 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene U2 spliceosomal RNA Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene transfer RNA threonine (anticodon AGU) 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbody abscission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 5-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 5-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; myotubularin-related protein 3
    Names
    phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    phosphatidylinositol-3-phosphate phosphatase
    NP_001012038.1
    XP_006251364.1
    XP_006251366.1
    XP_006251367.1
    XP_008768523.1
    XP_038947968.1
    XP_038947969.1
    XP_038947970.1
    XP_038947971.1
    XP_038947973.1
    XP_038947974.1
    XP_038947975.1
    XP_038947976.1
    XP_063129277.1
    XP_063129278.1
    XP_063129279.1
    XP_063129280.1
    XP_063129281.1
    XP_063129282.1
    XP_063129283.1
    XP_063129284.1
    XP_063129285.1
    XP_063129286.1
    XP_063129287.1
    XP_063129288.1
    XP_063129289.1
    XP_063129290.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012038.1NP_001012038.1  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

      See identical proteins and their annotated locations for NP_001012038.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087045
      UniProtKB/Swiss-Prot
      Q5PQT2
      UniProtKB/TrEMBL
      A0A0G2K8C7
      Related
      ENSRNOP00000054309.2, ENSRNOT00000057501.4
      Conserved Domains (3) summary
      cd13341
      Location:19112
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11111171
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      pfam06602
      Location:123519
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83564065..83684573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273211.1XP_063129281.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
    2. XM_039092046.2XP_038947974.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151175
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    3. XM_006251302.5XP_006251364.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006251364.1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    4. XM_063273214.1XP_063129284.1  myotubularin-related protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZLG1
    5. XM_063273207.1XP_063129277.1  myotubularin-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
    6. XM_039092045.2XP_038947973.1  myotubularin-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8C7
      Conserved Domains (3) summary
      cd13341
      Location:19112
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11111180
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:165481
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    7. XM_008770301.4XP_008768523.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008768523.1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    8. XM_006251305.5XP_006251367.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006251367.1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Related
      ENSRNOP00000089594.1, ENSRNOT00000113706.2
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    9. XM_039092043.2XP_038947971.1  myotubularin-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8C7
      Conserved Domains (3) summary
      cd13341
      Location:19112
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11111180
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:165481
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    10. XM_039092042.2XP_038947970.1  myotubularin-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    11. XM_039092041.2XP_038947969.1  myotubularin-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    12. XM_006251304.5XP_006251366.1  myotubularin-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006251366.1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    13. XM_039092040.2XP_038947968.1  myotubularin-related protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I6AAN8
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:11151184
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    14. XM_063273219.1XP_063129289.1  myotubularin-related protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K8C7
    15. XM_039092047.2XP_038947975.1  myotubularin-related protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZLG1
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:10781147
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    16. XM_063273220.1XP_063129290.1  myotubularin-related protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A0G2K8C7
    17. XM_063273218.1XP_063129288.1  myotubularin-related protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8C7, A6IKG6
    18. XM_063273213.1XP_063129283.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
    19. XM_063273215.1XP_063129285.1  myotubularin-related protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8C7, A6IKG6
      Related
      ENSRNOP00000078759.2, ENSRNOT00000116610.2
    20. XM_063273209.1XP_063129279.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
      Related
      ENSRNOP00000074555.3, ENSRNOT00000078838.3
    21. XM_063273217.1XP_063129287.1  myotubularin-related protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8C7, A6IKG6
    22. XM_063273212.1XP_063129282.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
    23. XM_063273216.1XP_063129286.1  myotubularin-related protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8C7, A6IKG6
    24. XM_039092048.2XP_038947976.1  myotubularin-related protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8C7, A6IKG6
      Conserved Domains (3) summary
      cd13341
      Location:23116
      PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15732
      Location:10781138
      FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins
      cd14586
      Location:169485
      PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
    25. XM_063273210.1XP_063129280.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8
    26. XM_063273208.1XP_063129278.1  myotubularin-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8C7, A0A8I5ZTK5, A6IKG8