Foxr1 forkhead box R1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxr1provided by RGD
Official Full Name: forkhead box R1provided by RGD
Primary source: RGD:1309739
See related: EnsemblRapid:ENSRNOG00000029089 AllianceGenome:RGD:1309739
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and sequence-specific double-stranded DNA binding activity. Predicted to be involved in brain development and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human FOXR1 (forkhead box R1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 6.6), Thymus (RPKM 2.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53657388..53669424, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44760587..44768696, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48754300..48762765, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein R1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429666.1 → NP_001416595.1 forkhead box protein R1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001429667.1 → NP_001416596.1 forkhead box protein R1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1LTW6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

53657388..53669424 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242969.5 → XP_006243031.1 forkhead box protein R1 isoform X2

Related

ENSRNOP00000050539.7, ENSRNOT00000049125.7

Conserved Domains (1) summary

pfam00250
Location:175 → 265

Forkhead; Forkhead domain
XM_006242968.5 → XP_006243030.1 forkhead box protein R1 isoform X1

Related

ENSRNOP00000112255.1, ENSRNOT00000122581.1

Conserved Domains (1) summary

pfam00250
Location:175 → 265

Forkhead; Forkhead domain
XM_039082340.2 → XP_038938268.1 forkhead box protein R1 isoform X3

Conserved Domains (1) summary

cd20036
Location:119 → 246

FH_FOXR; Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily
XM_039082343.2 → XP_038938271.1 forkhead box protein R1 isoform X5
XM_039082342.2 → XP_038938270.1 forkhead box protein R1 isoform X4