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    ND-B12 NADH dehydrogenase (ubiquinone) B12 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B12provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B12 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034645
    Locus tag
    Dmel_CG10320
    See related
    AllianceGenome:FB:FBgn0034645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10320; anon-EST:Posey47; anon-EST:Posey84; CG10320; Dmel\CG10320; dNDUFB3; NB2M; NDUFB3; Q9W2E8
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 25. Orthologous to human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B12 in Genome Data Viewer
    Location:
    57F6-57F6; 2-96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21658078..21658777)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17545583..17546282)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Inositol hexakisphosphate kinase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43786 Neighboring gene Rae1 Neighboring gene long non-coding RNA:CR44748 Neighboring gene poor Imd response upon knock-in

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO. Zhang F, et al. Mol Biol Cell, 2020 Jul 1. PMID 32374658, Free PMC Article
    2. Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex. Ebanks B, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769041, Free PMC Article
    3. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    4. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article
    5. Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state. Padavannil A, et al. Elife, 2023 Mar 23. PMID 36952377, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B12 subunit
    Names
    CG10320-PA
    CG10320-PB
    CG10320-PC
    CG10320-PD
    CG10320-PE
    NADH ubiquinone oxidoreductase B12
    NADH-ubiquinone oxidoreductase B12 subunit
    NADH:ubiquinone oxidoreductase B12 subunit
    ND-B12-PA
    ND-B12-PB
    ND-B12-PC
    ND-B12-PD
    ND-B12-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21658078..21658777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169770.2 → NP_001163241.1  NADH dehydrogenase (ubiquinone) B12 subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163241.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E8
      Conserved Domains (1) summary
      pfam08122
      Location:38 → 86
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family

    2. NM_001103929.3 → NP_001097399.1  NADH dehydrogenase (ubiquinone) B12 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E8
      Conserved Domains (1) summary
      pfam08122
      Location:38 → 86
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family

    3. NM_001169769.2 → NP_001163240.1  NADH dehydrogenase (ubiquinone) B12 subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E8
      Conserved Domains (1) summary
      pfam08122
      Location:38 → 86
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family

    4. NM_001103930.2 → NP_001097400.1  NADH dehydrogenase (ubiquinone) B12 subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E8
      Conserved Domains (1) summary
      pfam08122
      Location:38 → 86
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family

    5. NM_137752.5 → NP_611596.1  NADH dehydrogenase (ubiquinone) B12 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2E8
      Related
      FBpp0071580
      Conserved Domains (1) summary
      pfam08122
      Location:38 → 86
      NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2E8 Q9W2E8

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