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    CG18128 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18128provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034898
    Locus tag
    Dmel_CG18128
    See related
    AllianceGenome:FB:FBgn0034898
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18128
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Predicted to be involved in nucleoside metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18128 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23718798..23719936, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19606321..19607459, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene antisense RNA:CR45326 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sestrin Neighboring gene long non-coding RNA:CR45325 Neighboring gene mir-4979 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Lee JH, et al. Science, 2010 Mar 5. PMID 20203043, Free PMC Article
    2. A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection. Glittenberg MT, et al. Dis Model Mech, 2022 May 1. PMID 35142345, Free PMC Article
    3. A genomic response to the yeast transcription factor GAL4 in Drosophila. Liu Y, et al. Fly (Austin), 2008 Mar-Apr. PMID 18820459, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18128-PA
    NP_611822.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23718798..23719936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137978.2 → NP_611822.1  uncharacterized protein Dmel_CG18128 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NPB5, Q9W1K6
      Related
      FBpp0072003
      Conserved Domains (2) summary
      COG0005
      Location:50 → 280
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:46 → 280
      PNP_UDP_1; Phosphorylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1K6 Q9W1K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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