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    Nudt21 nudix hydrolase 21 [ Mus musculus (house mouse) ]

    Gene ID: 68219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nudt21provided by MGI
    Official Full Name
    nudix hydrolase 21provided by MGI
    Primary source
    MGI:MGI:1915469
    See related
    Ensembl:ENSMUSG00000031754 AllianceGenome:MGI:1915469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    25kDa; Cpsf5; 3110048P04Rik; 5730530J16Rik
    Summary
    Enables chromatin binding activity. Involved in positive regulation of pro-B cell differentiation; positive regulation of stem cell differentiation; and post-transcriptional regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; respiratory system; and sensory organ. Orthologous to human NUDT21 (nudix hydrolase 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 99.8), ovary adult (RPKM 79.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nudt21 in Genome Data Viewer
    Location:
    8 C5; 8 46.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94746031..94763667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94019403..94037039, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha O Neighboring gene VISTA enhancer mm1458 Neighboring gene predicted gene, 53411 Neighboring gene autocrine motility factor receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Neighboring gene Bardet-Biedl syndrome 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA alternative polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA alternative polyadenylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-transcriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mRNA cleavage factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cleavage factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
     
    located_in paraspeckles ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cleavage and polyadenylation specificity factor subunit 5
    Names
    cleavage and polyadenylation specific factor 5, 25 kD subunit
    nucleoside diphosphate-linked moiety X motif 21
    nudix (nucleoside diphosphate linked moiety X)-type motif 21
    nudix motif 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026623.3NP_080899.1  cleavage and polyadenylation specificity factor subunit 5

      See identical proteins and their annotated locations for NP_080899.1

      Status: VALIDATED

      Source sequence(s)
      AC138118, AK011688
      Consensus CDS
      CCDS40433.1
      UniProtKB/Swiss-Prot
      Q3UJK1, Q9CQF3
      UniProtKB/TrEMBL
      A0A1D5RM23
      Related
      ENSMUSP00000034204.10, ENSMUST00000034204.11
      Conserved Domains (1) summary
      pfam13869
      Location:35222
      NUDIX_2; Nucleotide hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94746031..94763667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)