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    Stk11 serine/threonine kinase 11 [ Mus musculus (house mouse) ]

    Gene ID: 20869, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stk11provided by MGI
    Official Full Name
    serine/threonine kinase 11provided by MGI
    Primary source
    MGI:MGI:1341870
    See related
    Ensembl:ENSMUSG00000003068 AllianceGenome:MGI:1341870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lkb1; Par-4
    Summary
    This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in thymus adult (RPKM 32.5), testis adult (RPKM 30.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stk11 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79951602..79966513)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80115767..80130679)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27262 Neighboring gene STARR-positive B cell enhancer ABC_E900 Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene ATP synthase F1 subunit delta Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene midnolin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (20)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables LRR domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1 to G0 transition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Golgi localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV-B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucagon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to lipid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to thyroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intracellular protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of intracellular protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine/threonine protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine/threonine protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase STK11
    Names
    liver kinase B1 homolog
    serine/threonine-protein kinase 11
    serine/threonine-protein kinase LKB1
    NP_001288782.1
    NP_001288783.1
    NP_035622.1
    XP_006513502.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301853.2NP_001288782.1  serine/threonine-protein kinase STK11 isoform S

      See identical proteins and their annotated locations for NP_001288782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (S, see PMID:18774945) has a distinct C-terminus and is shorter than isoform L.
      Source sequence(s)
      AC159999
      Consensus CDS
      CCDS78854.1
      UniProtKB/Swiss-Prot
      Q9WTK7
      Related
      ENSMUSP00000114195.2, ENSMUST00000144883.8
      Conserved Domains (2) summary
      smart00220
      Location:49309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
    2. NM_001301854.2NP_001288783.1  serine/threonine-protein kinase STK11 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform L.
      Source sequence(s)
      AC159999
      UniProtKB/TrEMBL
      E9Q811
      Related
      ENSMUSP00000101009.2, ENSMUST00000105370.8
      Conserved Domains (2) summary
      smart00220
      Location:1185
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1185
      PKc_like; Protein Kinases, catalytic domain
    3. NM_011492.5NP_035622.1  serine/threonine-protein kinase STK11 isoform L

      See identical proteins and their annotated locations for NP_035622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (L, see PMID:18774945).
      Source sequence(s)
      AC159999
      Consensus CDS
      CCDS35974.1
      UniProtKB/Swiss-Prot
      A0A2L1DGD8, B3VBP0, Q3TAE0, Q9WTK7
      Related
      ENSMUSP00000003152.8, ENSMUST00000003152.14
      Conserved Domains (2) summary
      smart00220
      Location:49309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

    RNA

    1. NR_126043.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in the variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159999

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79951602..79966513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513439.5XP_006513502.1  serine/threonine-protein kinase STK11 isoform X1

      UniProtKB/TrEMBL
      Q9R0P1
      Conserved Domains (1) summary
      cd14119
      Location:79291
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

    RNA

    1. XR_003948638.2 RNA Sequence

    2. XR_004936136.1 RNA Sequence