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    Birc2 baculoviral IAP repeat-containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 11797, updated on 9-Dec-2024

    Summary

    Official Symbol
    Birc2provided by MGI
    Official Full Name
    baculoviral IAP repeat-containing 2provided by MGI
    Primary source
    MGI:MGI:1197009
    See related
    Ensembl:ENSMUSG00000057367 AllianceGenome:MGI:1197009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc3; HIAP1; HIAP2; MIAP1; MIAP2; RNF48; cIAP1; cIAP2; C-IAP1; mcIAP1; C330006D17Rik
    Summary
    Enables ubiquitin-protein transferase activity. Involved in necroptotic process and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including cellular response to tumor necrosis factor; negative regulation of necroptotic process; and negative regulation of ripoptosome assembly involved in necroptotic process. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including central nervous system; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BIRC2 (baculoviral IAP repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.0), CNS E14 (RPKM 8.3) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Birc2 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7818227..7837123, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7818226..7837131, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2884 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7764868-7765169 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene transmembrane protein 123 Neighboring gene STARR-seq mESC enhancer starr_23223 Neighboring gene microRNA 5618 Neighboring gene STARR-seq mESC enhancer starr_23227 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7872853-7873154 Neighboring gene STARR-positive B cell enhancer mm9_chr9:7873159-7873459 Neighboring gene baculoviral IAP repeat-containing 3 Neighboring gene STARR-seq mESC enhancer starr_23228 Neighboring gene STARR-seq mESC enhancer starr_23230 Neighboring gene STARR-seq mESC enhancer starr_23231 Neighboring gene yes-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_23234 Neighboring gene STARR-seq mESC enhancer starr_23236 Neighboring gene STARR-seq mESC enhancer starr_23238

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FBXO family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FBXO family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of ripoptosome assembly involved in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in XY body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in XY body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    baculoviral IAP repeat-containing protein 2
    Names
    RING-type E3 ubiquitin transferase BIRC2
    apoptosis inhibitor 2
    baculoviral IAP repeat-containing 3
    cellular inhibitor of apoptosis 1
    inhibitor of apoptosis protein 2
    NP_001278432.1
    NP_031491.2
    XP_017168599.1
    XP_017168600.1
    XP_030099889.1
    XP_036010465.1
    XP_036010466.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291503.2NP_001278432.1  baculoviral IAP repeat-containing protein 2

      See identical proteins and their annotated locations for NP_001278432.1

      Status: VALIDATED

      Source sequence(s)
      CT030639
      Consensus CDS
      CCDS22811.1
      UniProtKB/Swiss-Prot
      A6H6S7, O08864, Q62210
      Conserved Domains (5) summary
      smart00238
      Location:176245
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:447538
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:559612
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    2. NM_007465.4NP_031491.2  baculoviral IAP repeat-containing protein 2

      See identical proteins and their annotated locations for NP_031491.2

      Status: VALIDATED

      Source sequence(s)
      CT030639
      Consensus CDS
      CCDS22811.1
      UniProtKB/Swiss-Prot
      A6H6S7, O08864, Q62210
      Related
      ENSMUSP00000140049.2, ENSMUST00000190341.7
      Conserved Domains (5) summary
      smart00238
      Location:176245
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:447538
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:559612
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7818227..7837123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313111.2XP_017168600.1  baculoviral IAP repeat-containing protein 2 isoform X2

      Conserved Domains (5) summary
      smart00238
      Location:45114
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:474527
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:180244
      BIR; Inhibitor of Apoptosis domain
    2. XM_030244029.2XP_030099889.1  baculoviral IAP repeat-containing protein 2 isoform X2

      Conserved Domains (5) summary
      smart00238
      Location:45114
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:474527
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:180244
      BIR; Inhibitor of Apoptosis domain
    3. XM_036154572.1XP_036010465.1  baculoviral IAP repeat-containing protein 2 isoform X2

      Conserved Domains (5) summary
      smart00238
      Location:45114
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:474527
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:180244
      BIR; Inhibitor of Apoptosis domain
    4. XM_017313110.2XP_017168599.1  baculoviral IAP repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6H6S7, O08864, Q62210
      Related
      ENSMUSP00000091422.5, ENSMUST00000074246.7
      Conserved Domains (5) summary
      smart00238
      Location:176245
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd08329
      Location:447538
      CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
      cd14394
      Location:385431
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:559612
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    5. XM_036154573.1XP_036010466.1  baculoviral IAP repeat-containing protein 2 isoform X3

      Conserved Domains (3) summary
      smart00238
      Location:45114
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:263329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      pfam00653
      Location:180244
      BIR; Inhibitor of Apoptosis domain

    RNA

    1. XR_004935314.1 RNA Sequence

    2. XR_004935313.1 RNA Sequence