U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mesp2 mesoderm posterior 2 [ Mus musculus (house mouse) ]

    Gene ID: 17293, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mesp2provided by MGI
    Official Full Name
    mesoderm posterior 2provided by MGI
    Primary source
    MGI:MGI:1096325
    See related
    Ensembl:ENSMUSG00000030543 AllianceGenome:MGI:1096325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bHLHc6
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including mesodermal cell migration; signal transduction involved in regulation of gene expression; and somite rostral/caudal axis specification. Located in nucleus. Is expressed in several structures, including central nervous system; ear; embryo mesoderm; genitourinary system; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 2. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 3.6), ovary adult (RPKM 2.8) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mesp2 in Genome Data Viewer
    Location:
    7 D2; 7 45.18 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79460475..79463179)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79810727..79813431)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 44705 Neighboring gene mesoderm posterior 1 Neighboring gene alanyl aminopeptidase, membrane Neighboring gene adaptor-related protein complex 3, sigma 2 subunit Neighboring gene STARR-seq mESC enhancer starr_19292 Neighboring gene RIKEN cDNA 5430400D12 gene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (23)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mesodermal cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in somite rostral/caudal axis specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mesoderm posterior protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008589.2NP_032615.2  mesoderm posterior protein 2

      See identical proteins and their annotated locations for NP_032615.2

      Status: VALIDATED

      Source sequence(s)
      AC109221, AK146740
      Consensus CDS
      CCDS39993.1
      UniProtKB/TrEMBL
      A6H5V4
      Related
      ENSMUSP00000103017.2, ENSMUST00000107394.3
      Conserved Domains (1) summary
      pfam00010
      Location:80133
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79460475..79463179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)