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    Slc22a27 solute carrier family 22, member 27 [ Mus musculus (house mouse) ]

    Gene ID: 171405, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a27provided by MGI
    Official Full Name
    solute carrier family 22, member 27provided by MGI
    Primary source
    MGI:MGI:3042283
    See related
    Ensembl:ENSMUSG00000067656 AllianceGenome:MGI:3042283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oat9; OAT6-L; OAT6-S
    Summary
    Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 10.2) and kidney adult (RPKM 4.4) See more
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    Genomic context

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    See Slc22a27 in Genome Data Viewer
    Location:
    19 A; 19 5.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7841753..7943899, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7864388..7966517, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 26 Neighboring gene STARR-seq mESC enhancer starr_45473 Neighboring gene solute carrier family 22 (organic cation transporter), member 26 pseudogene Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene calpastatin pseudogene Neighboring gene solute carrier family 22, member 28 Neighboring gene STARR-seq mESC enhancer starr_45475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. Tsuchida H, et al. Cell Physiol Biochem, 2010. PMID 20332632
    2. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oat9S appears to be the first member to mediate the transport of carnitine and possesses eight transmembrane domains.
      Title: Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 27
    Names
    mOAT6 related protein
    organic anion transporter 6
    organic anion transporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361980.1 → NP_001348909.1  solute carrier family 22 member 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115715, AC122119
      Consensus CDS
      CCDS89333.1
      Related
      ENSMUSP00000138475.2, ENSMUST00000182102.8
      Conserved Domains (1) summary
      cl26863
      Location:11 → 416
      Sugar_tr; Sugar (and other) transporter

    2. NM_134256.1 → NP_599017.1  solute carrier family 22 member 27 isoform 1

      See identical proteins and their annotated locations for NP_599017.1

      Status: VALIDATED

      Source sequence(s)
      AB056442
      Consensus CDS
      CCDS50380.1
      UniProtKB/Swiss-Prot
      Q76M71, Q76M72
      UniProtKB/TrEMBL
      Q687I4
      Related
      ENSMUSP00000093991.2, ENSMUST00000075619.5
      Conserved Domains (1) summary
      cd17374
      Location:109 → 515
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7841753..7943899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526728.3 → XP_006526791.1  solute carrier family 22 member 27 isoform X2

      See identical proteins and their annotated locations for XP_006526791.1

      UniProtKB/Swiss-Prot
      Q76M71, Q76M72
      UniProtKB/TrEMBL
      Q687I4
      Conserved Domains (1) summary
      cd17374
      Location:109 → 515
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    2. XM_017318076.3 → XP_017173565.1  solute carrier family 22 member 27 isoform X1

      UniProtKB/TrEMBL
      Q687I4
      Conserved Domains (1) summary
      cd17374
      Location:134 → 540
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    3. XM_017318077.3 → XP_017173566.1  solute carrier family 22 member 27 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:137 → 307
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76M72.1 GenPept UniProtKB/Swiss-Prot:Q76M72

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