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    Enc1 ectodermal-neural cortex 1 [ Mus musculus (house mouse) ]

    Gene ID: 13803, updated on 9-Dec-2024

    Summary

    Official Symbol
    Enc1provided by MGI
    Official Full Name
    ectodermal-neural cortex 1provided by MGI
    Primary source
    MGI:MGI:109610
    See related
    Ensembl:ENSMUSG00000041773 AllianceGenome:MGI:109610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrpb; PIG10
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in several processes, including negative regulation of translation; positive regulation of neuron projection development; and proteasomal ubiquitin-independent protein catabolic process. Predicted to be located in chromatin; neuronal cell body; and nuclear lumen. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 112.0), whole brain E14.5 (RPKM 85.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Enc1 in Genome Data Viewer
    Location:
    13 50.66 cM; 13 D1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97377613..97389548)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97241105..97253040)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene STARR-positive B cell enhancer ABC_E3094 Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene STARR-seq mESC enhancer starr_35367 Neighboring gene hexosaminidase B Neighboring gene STARR-seq mESC enhancer starr_35370 Neighboring gene STARR-seq mESC enhancer starr_35377 Neighboring gene predicted gene, 33390 Neighboring gene STARR-seq mESC enhancer starr_35381 Neighboring gene STARR-seq mESC enhancer starr_35383 Neighboring gene predicted gene, 33447

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasomal ubiquitin-independent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal ubiquitin-independent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ectoderm-neural cortex protein 1
    Names
    ENC-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007930.4NP_031956.3  ectoderm-neural cortex protein 1

      See identical proteins and their annotated locations for NP_031956.3

      Status: VALIDATED

      Source sequence(s)
      AK132173, AV465735
      Consensus CDS
      CCDS26710.1
      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Related
      ENSMUSP00000038783.8, ENSMUST00000041623.9
      Conserved Domains (4) summary
      PHA03098
      Location:48566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97377613..97389548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247139.1XP_030102999.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
    2. XM_030247137.1XP_030102997.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)
    3. XM_030247138.1XP_030102998.1  ectoderm-neural cortex protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O35709, Q8C7V2
      UniProtKB/TrEMBL
      Q8BRG4
      Conserved Domains (4) summary
      PHA03098
      Location:48566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330374
      Kelch; KELCH repeat [structural motif]
      cd18267
      Location:6152
      BTB_POZ_KLHL37_ENC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1)
      cd18515
      Location:145242
      BACK_KLHL37_ENC1; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37)