B3galt6 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: B3galt6provided by MGI
Official Full Name: UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6provided by MGI
Primary source: MGI:MGI:2152819
See related: Ensembl:ENSMUSG00000050796 AllianceGenome:MGI:2152819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GalTII
Summary: Enables galactosylxylosylprotein 3-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Located in Golgi medial cisterna. Is active in Golgi apparatus. Is expressed in medial ganglionic eminence. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 E2; 4 87.66 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156073923..156077135, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155989466..155992678, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

BB129894 (e-PCR)
- UniSTS:185612

D4Mon1 (e-PCR)
- UniSTS:240974

D4Mon40 (e-PCR)
- UniSTS:241001

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycosaminoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycosaminoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosaminoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: beta-1,3-galactosyltransferase 6

Names: GAG GalTII; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6; beta-1,3-GalTase 6; beta3Gal-T6; beta3GalT6; galactosyltransferase II; galactosylxylosylprotein 3-beta-galactosyltransferase

NP_536693.1

EC 2.4.1.134

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.