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    Pde4b phosphodiesterase 4B, cAMP specific [ Mus musculus (house mouse) ]

    Gene ID: 18578, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pde4bprovided by MGI
    Official Full Name
    phosphodiesterase 4B, cAMP specificprovided by MGI
    Primary source
    MGI:MGI:99557
    See related
    Ensembl:ENSMUSG00000028525 AllianceGenome:MGI:99557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dpde4; dunce
    Summary
    Enables gamma-tubulin binding activity. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including centrosome; postsynaptic density; and synaptic vesicle. Part of gamma-tubulin complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 9.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pde4b in Genome Data Viewer
    Location:
    4 C6; 4 46.99 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101944529..102464459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102087332..102607275)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10922 Neighboring gene STARR-seq mESC enhancer starr_10923 Neighboring gene PRAME like 62 Neighboring gene STARR-seq mESC enhancer starr_10924 Neighboring gene RNA binding motif protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10925 Neighboring gene predicted gene, 52669 Neighboring gene zinc finger protein 352 pseudogene Neighboring gene zinc finger protein 352 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10926 Neighboring gene STARR-positive B cell enhancer ABC_E3498 Neighboring gene STARR-positive B cell enhancer mm9_chr4:102178342-102178642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184116-102184299 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184409-102184518 Neighboring gene STARR-positive B cell enhancer ABC_E4639 Neighboring gene STARR-positive B cell enhancer ABC_E1034 Neighboring gene predicted gene, 52668 Neighboring gene STARR-seq mESC enhancer starr_10927 Neighboring gene predicted gene, 52667 Neighboring gene predicted gene, 24869 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene predicted gene 12709

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of gamma-tubulin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4B
    NP_001171451.1
    NP_001171452.1
    NP_001171453.1
    NP_001171454.1
    NP_001361709.1
    NP_001391715.1
    NP_001391716.1
    NP_001391717.1
    NP_001391718.1
    NP_001391720.1
    NP_001391722.1
    NP_001391723.1
    NP_001391725.1
    NP_001391733.1
    NP_001391765.1
    NP_062814.2
    XP_006502919.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177980.2NP_001171451.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but has an alternate 5' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL732551, AL772358
      Consensus CDS
      CCDS51243.1
      UniProtKB/TrEMBL
      B1AWD0, Q91VY2
      Related
      ENSMUSP00000095562.3, ENSMUST00000097950.9
      Conserved Domains (1) summary
      pfam00233
      Location:233474
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001177981.1NP_001171452.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

      See identical proteins and their annotated locations for NP_001171452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL732551, BB654856, BC071259
      Consensus CDS
      CCDS51244.1
      UniProtKB/TrEMBL
      Q6IQY6, Q91VY2
      Related
      ENSMUSP00000095561.5, ENSMUST00000097949.11
      Conserved Domains (1) summary
      pfam00233
      Location:172413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. NM_001177982.1NP_001171453.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 4

      See identical proteins and their annotated locations for NP_001171453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK161341, AL732551
      Consensus CDS
      CCDS51245.1
      UniProtKB/TrEMBL
      Q3TTI9, Q91VY2
      Related
      ENSMUSP00000030251.7, ENSMUST00000030251.13
      Conserved Domains (1) summary
      pfam00233
      Location:153394
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. NM_001177983.2NP_001171454.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 5

      See identical proteins and their annotated locations for NP_001171454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (5) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL772293, AL772358
      Consensus CDS
      CCDS57289.1
      UniProtKB/TrEMBL
      Q80VK8
      Related
      ENSMUSP00000102520.3, ENSMUST00000106907.9
    5. NM_001374780.2NP_001361709.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358, AL807794
      Consensus CDS
      CCDS89787.1
      UniProtKB/TrEMBL
      B1AWC8, Q9QXI7
      Related
      ENSMUSP00000102517.3, ENSMUST00000106904.9
      Conserved Domains (2) summary
      pfam00233
      Location:328569
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89204
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    6. NM_001404786.1NP_001391715.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358
      UniProtKB/TrEMBL
      B1AWC9, Q9QXI7
      Related
      ENSMUSP00000102524.2, ENSMUST00000106911.8
    7. NM_001404787.1NP_001391716.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL772293, AL772358
    8. NM_001404788.1NP_001391717.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL772293, AL772358
    9. NM_001404789.1NP_001391718.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358, AL807794
      UniProtKB/TrEMBL
      B1AWC8, Q9QXI7
    10. NM_001404791.1NP_001391720.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358
      UniProtKB/TrEMBL
      Q9QXI7
    11. NM_001404793.1NP_001391722.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358
      UniProtKB/TrEMBL
      Q91VY2
    12. NM_001404794.1NP_001391723.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358
    13. NM_001404796.1NP_001391725.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358
    14. NM_001404804.1NP_001391733.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358
      UniProtKB/TrEMBL
      Q91VY2
    15. NM_001404836.1NP_001391765.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358
    16. NM_019840.3NP_062814.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_062814.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL732551, AL772293, AL772358
      Consensus CDS
      CCDS18403.1
      UniProtKB/TrEMBL
      Q8VBU5, Q9QXI7
      Related
      ENSMUSP00000102521.3, ENSMUST00000106908.9
      Conserved Domains (1) summary
      pfam00233
      Location:390631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101944529..102464459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502856.2XP_006502919.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      Q9QXI7
      Conserved Domains (2) summary
      pfam00233
      Location:344585
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:105220
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    RNA

    1. XR_004941842.1 RNA Sequence