Agmat agmatinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agmatprovided by MGI
Official Full Name: agmatinaseprovided by MGI
Primary source: MGI:MGI:1923236
See related: Ensembl:ENSMUSG00000040706 AllianceGenome:MGI:1923236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5033405N08Rik
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines. Predicted to be involved in putrescine biosynthetic process from arginine, using agmatinase. Predicted to be located in mitochondrion. Orthologous to human AGMAT (agmatinase (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 179.8), duodenum adult (RPKM 26.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 74.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141473986..141486574)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141746675..141759263)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings implicate Agmat in the depressive-like phenotype of Crtc1(-/-) mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression.
Title: Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.
It thus appears that mammalian AGMs form a distinct group within the family of ureahydrolases that (i) either fold in a manner distinct from other members in this family, or (ii) require accessory proteins to bind Mn(2+) in a mechanism related to that observed for the Ni(2+)-dependent urease.
Title: Mammalian agmatinases constitute unusual members in the family of Mn(2+)-dependent ureahydrolases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables agmatinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables agmatinase activity	IEA Inferred from Electronic Annotation more info
enables arginase activity	ISO Inferred from Sequence Orthology more info
enables arginase activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanidinobutyrase activity	ISO Inferred from Sequence Orthology more info
enables guanidinobutyrase activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanidinopropionase activity	ISO Inferred from Sequence Orthology more info
enables guanidinopropionase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in putrescine biosynthetic process from arginine, using agmatinase	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanidino acid hydrolase, mitochondrial

Names: AUH; agmatinase, mitochondrial; agmatine ureohydrolase (agmatinase); arginase, mitochondrial; guanidinobutyrase, mitochondrial; guanidinopropionase, mitochondrial

NP_001074877.1

EC 3.5.3.1

EC 3.5.3.17

EC 3.5.3.7

NP_001365791.1

EC 3.5.3.1

EC 3.5.3.17

EC 3.5.3.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081408.1 → NP_001074877.1 guanidino acid hydrolase, mitochondrial isoform 2 precursor

See identical proteins and their annotated locations for NP_001074877.1

Status: VALIDATED

Source sequence(s)

AL928577

Consensus CDS

CCDS38941.1

UniProtKB/Swiss-Prot

A2AS89, Q14BN7

Related

ENSMUSP00000040853.5, ENSMUST00000038161.5

Conserved Domains (1) summary

cd11592
Location:61 → 349

Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase
NM_001378862.1 → NP_001365791.1 guanidino acid hydrolase, mitochondrial isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL928577

Conserved Domains (1) summary

cd11592
Location:61 → 357

Agmatinase_PAH; Agmatinase-like family includes proclavaminic acid amidinohydrolase