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    Bex3 brain expressed X-linked 3 [ Mus musculus (house mouse) ]

    Gene ID: 12070, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bex3provided by MGI
    Official Full Name
    brain expressed X-linked 3provided by MGI
    Primary source
    MGI:MGI:1338016
    See related
    Ensembl:ENSMUSG00000046432 AllianceGenome:MGI:1338016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nade; Gcap27; Ngfrap1; DXWsu67e
    Summary
    Enables death receptor binding activity and molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; liver; nervous system; and sensory organ. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 289.2), CNS E18 (RPKM 196.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bex3 in Genome Data Viewer
    Location:
    X F1; X 57.64 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135171002..135172727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136270253..136271978)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39535 Neighboring gene transcription elongation factor A like 9 Neighboring gene nuclear encoded rRNA 5S 12 Neighboring gene STARR-seq mESC enhancer starr_47977 Neighboring gene NSA2 ribosome biogenesis homolog, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Kim AJ, et al. Gene, 2004 Dec 8. PMID 15563833
    2. Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome. Brown AL, et al. Hum Mol Genet, 1999 Apr. PMID 10072429
    3. Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. Calvo L, et al. J Neurosci, 2015 May 6. PMID 25948268, Free PMC Article
    4. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Yoon K, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178455
    5. Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis. Kendall SE, et al. Brain Res Dev Brain Res, 2003 Sep 10. PMID 12935912

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.
      Title: Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.
    2. NADE mRNA level remained invariant across development.
      Title: Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis.
    3. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis
      Title: Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis.
    4. In situ hybridization demonstrates cellular co-localization of olfactory marker protein mRNA with mRNAs for Bex1, Bex2, and Bex3 in olfactory receptor neuronss in olfactory tissue of the mouse
      Title: Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables death receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nerve growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nerve growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein BEX3
    Names
    brain-expressed X-linked protein 3 homolog
    granule cell antiserum positive 27
    nerve growth factor receptor (TNFRSF16) associated protein 1
    nerve growth factor receptor-associated protein 1
    p75NTR-associated Cell Death Executor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110233.1 → NP_001103703.1  protein BEX3 isoform a

      See identical proteins and their annotated locations for NP_001103703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AA681927, AV574205, AV575702, CD774851, CF618290
      Consensus CDS
      CCDS30419.1
      UniProtKB/Swiss-Prot
      A3KGA0, A3KGA1, Q9CWN9, Q9D0S2, Q9D1N5, Q9WTZ9
      Related
      ENSMUSP00000136952.2, ENSMUST00000178632.8
      Conserved Domains (1) summary
      pfam04538
      Location:1 → 120
      BEX; Brain expressed X-linked like family

    2. NM_001110234.1 → NP_001103704.1  protein BEX3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AA681927, AV575702, CB055608, CD774851
      Consensus CDS
      CCDS53194.1
      UniProtKB/Swiss-Prot
      Q9WTZ9
      Related
      ENSMUSP00000108737.2, ENSMUST00000113112.2
      Conserved Domains (1) summary
      pfam04538
      Location:1 → 110
      BEX; Brain expressed X-linked like family

    3. NM_009750.2 → NP_033880.1  protein BEX3 isoform a

      See identical proteins and their annotated locations for NP_033880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AA681927, AV575702, CD774851, CF618290
      Consensus CDS
      CCDS30419.1
      UniProtKB/Swiss-Prot
      A3KGA0, A3KGA1, Q9CWN9, Q9D0S2, Q9D1N5, Q9WTZ9
      Related
      ENSMUSP00000063039.5, ENSMUST00000053540.11
      Conserved Domains (1) summary
      pfam04538
      Location:1 → 120
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135171002..135172727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTZ9.1 GenPept UniProtKB/Swiss-Prot:Q9WTZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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