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    Rmc1 regulator of MON1-CCZ1 [ Mus musculus (house mouse) ]

    Gene ID: 76482, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rmc1provided by MGI
    Official Full Name
    regulator of MON1-CCZ1provided by MGI
    Primary source
    MGI:MGI:1916528
    See related
    Ensembl:ENSMUSG00000024410 AllianceGenome:MGI:1916528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mic1; Mic-1; Wdr98; 2400010D15Rik; 3110002H16Rik
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to be located in lysosomal membrane. Predicted to be part of Mon1-Ccz1 complex. Predicted to be active in late endosome membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human RMC1 (regulator of MON1-CCZ1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 20.0), liver E14 (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rmc1 in Genome Data Viewer
    Location:
    18 A1; 18 6.15 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12301746..12331732)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12168689..12198675)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4239 Neighboring gene STARR-positive B cell enhancer ABC_E3223 Neighboring gene RIO kinase 3 Neighboring gene predicted gene, 25289 Neighboring gene predicted gene, 19293 Neighboring gene STARR-positive B cell enhancer ABC_E2504 Neighboring gene STARR-seq mESC enhancer starr_43833 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ecotropic viral integration site 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43835 Neighboring gene laminin, alpha 3 Neighboring gene predicted gene, 36232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Loftus SK, et al. Science, 1997 Jul 11. PMID 9211850
    2. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Darakhshan F, et al. Carcinogenesis, 2006 Feb. PMID 16093251
    3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • AC102096.3

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Mon1-Ccz1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mon1-Ccz1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Mon1-Ccz1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of MON1-CCZ1 complex
    Names
    colon cancer-associated protein Mic1 homolog
    uncharacterized protein C18orf8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029623.2 → NP_083899.1  regulator of MON1-CCZ1 complex

      See identical proteins and their annotated locations for NP_083899.1

      Status: VALIDATED

      Source sequence(s)
      AF003352, AK144623, AK159691
      Consensus CDS
      CCDS29063.1
      UniProtKB/Swiss-Prot
      O35606, Q8VC42
      UniProtKB/TrEMBL
      Q3U4H5, Q3UMX3
      Related
      ENSMUSP00000025276.9, ENSMUST00000025276.15
      Conserved Domains (1) summary
      pfam07035
      Location:475 → 631
      Mic1; Colon cancer-associated protein Mic1-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12301746..12331732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526341.3 → XP_006526404.1  regulator of MON1-CCZ1 complex isoform X1

      UniProtKB/TrEMBL
      Q3UMX3
      Conserved Domains (1) summary
      pfam07035
      Location:475 → 632
      Mic1; Colon cancer-associated protein Mic1-like

    2. XM_006526342.5 → XP_006526405.1  regulator of MON1-CCZ1 complex isoform X2

      UniProtKB/TrEMBL
      Q3UMX3
      Conserved Domains (1) summary
      pfam07035
      Location:421 → 578
      Mic1; Colon cancer-associated protein Mic1-like

    RNA

    1. XR_386019.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC42.1 GenPept UniProtKB/Swiss-Prot:Q8VC42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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