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    Lcorl ligand dependent nuclear receptor corepressor-like [ Mus musculus (house mouse) ]

    Gene ID: 209707, updated on 3-Dec-2024

    Summary

    Official Symbol
    Lcorlprovided by MGI
    Official Full Name
    ligand dependent nuclear receptor corepressor-likeprovided by MGI
    Primary source
    MGI:MGI:2651932
    See related
    Ensembl:ENSMUSG00000015882 AllianceGenome:MGI:2651932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlr1; Gm3414
    Summary
    Predicted to enable histone methyltransferase binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; oocyte; retina; and trunk somite. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 2.2), CNS E18 (RPKM 2.0) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lcorl in Genome Data Viewer
    Location:
    5 B3; 5 25.31 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45854523..46015213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45697181..45857835, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13005 Neighboring gene RIKEN cDNA 1600023N17 gene Neighboring gene STARR-positive B cell enhancer ABC_E1300 Neighboring gene DDB1 and CUL4 associated factor 16 pseudogene Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene DNA-directed RNA polymerase III subunit RPC6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:46248894-46249195 Neighboring gene RIKEN cDNA 4930405L22 gene Neighboring gene STARR-seq mESC enhancer starr_13008 Neighboring gene predicted gene, 40298

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ligand-dependent nuclear receptor corepressor-like protein
    Names
    LCoR-like protein
    Mblk1-related protein-1
    mblk1-related protein 1
    transcription factor MLR1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163073.2NP_001156545.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

      See identical proteins and their annotated locations for NP_001156545.1

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS51499.1
      UniProtKB/Swiss-Prot
      B2RRS7, Q3U285, Q6NZG1, Q8BNH5, Q8BRN7, Q8BRT8, Q8C9J6, Q8CJG4
      Related
      ENSMUSP00000016026.8, ENSMUST00000016026.14
      Conserved Domains (1) summary
      pfam05225
      Location:525570
      HTH_psq; helix-turn-helix, Psq domain
    2. NM_001359871.2NP_001346800.1  ligand-dependent nuclear receptor corepressor-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A0H2UH31
      Related
      ENSMUSP00000140503.3, ENSMUST00000190036.7
    3. NM_001359872.2NP_001346801.1  ligand-dependent nuclear receptor corepressor-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS89917.1
      UniProtKB/TrEMBL
      E9PXY2, Q8C9B1
      Related
      ENSMUSP00000112416.2, ENSMUST00000121573.8
    4. NM_001359873.2NP_001346802.1  ligand-dependent nuclear receptor corepressor-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Related
      ENSMUST00000067997.11
    5. NM_001359874.2NP_001346803.1  ligand-dependent nuclear receptor corepressor-like protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A087WST0
    6. NM_001428433.1NP_001415362.1  ligand-dependent nuclear receptor corepressor-like protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A571BEC4
    7. NM_001428434.1NP_001415363.1  ligand-dependent nuclear receptor corepressor-like protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    8. NM_001428435.1NP_001415364.1  ligand-dependent nuclear receptor corepressor-like protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    9. NM_001428436.1NP_001415365.1  ligand-dependent nuclear receptor corepressor-like protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    10. NM_001428437.1NP_001415366.1  ligand-dependent nuclear receptor corepressor-like protein isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    11. NM_001428438.1NP_001415367.1  ligand-dependent nuclear receptor corepressor-like protein isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    12. NM_001428439.1NP_001415368.1  ligand-dependent nuclear receptor corepressor-like protein isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      UniProtKB/TrEMBL
      A0A0H2UH31
    13. NM_001428440.1NP_001415369.1  ligand-dependent nuclear receptor corepressor-like protein isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    14. NM_001428441.1NP_001415370.1  ligand-dependent nuclear receptor corepressor-like protein isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    15. NM_001428442.1NP_001415371.1  ligand-dependent nuclear receptor corepressor-like protein isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    16. NM_001428443.1NP_001415372.1  ligand-dependent nuclear receptor corepressor-like protein isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    17. NM_001428444.1NP_001415373.1  ligand-dependent nuclear receptor corepressor-like protein isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
    18. NM_172153.4NP_742165.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

      See identical proteins and their annotated locations for NP_742165.1

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS19278.1
      UniProtKB/Swiss-Prot
      Q3U285
      Related
      ENSMUSP00000084408.4, ENSMUST00000087164.10
      Conserved Domains (1) summary
      pfam05225
      Location:442487
      HTH_psq; helix-turn-helix, Psq domain
    19. NM_178142.6NP_835278.2  ligand-dependent nuclear receptor corepressor-like protein isoform 3

      See identical proteins and their annotated locations for NP_835278.2

      Status: VALIDATED

      Source sequence(s)
      AC093341, AC158786
      Consensus CDS
      CCDS19277.1
      UniProtKB/Swiss-Prot
      Q3U285
      Related
      ENSMUSP00000042677.7, ENSMUST00000045586.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      45854523..46015213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      45877009..45884920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503818.5XP_006503881.1  ligand-dependent nuclear receptor corepressor-like protein isoform X1

      Related
      ENSMUSP00000158672.2, ENSMUST00000238522.2
      Conserved Domains (1) summary
      pfam15090
      Location:14021846
      DUF4553; Domain of unknown function (DUF4553)
    2. XM_036164968.1XP_036020861.1  ligand-dependent nuclear receptor corepressor-like protein isoform X2

      Conserved Domains (1) summary
      pfam15090
      Location:13321776
      DUF4553; Domain of unknown function (DUF4553)
    3. XM_030254342.2XP_030110202.1  ligand-dependent nuclear receptor corepressor-like protein isoform X7

      UniProtKB/TrEMBL
      E9PXY2, Q8C9B1
    4. XM_036164972.1XP_036020865.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      Conserved Domains (1) summary
      pfam05225
      Location:366411
      HTH_psq; helix-turn-helix, Psq domain
    5. XM_030254341.2XP_030110201.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

      Conserved Domains (1) summary
      pfam05225
      Location:439484
      HTH_psq; helix-turn-helix, Psq domain
    6. XM_036164971.1XP_036020864.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

      Conserved Domains (1) summary
      pfam05225
      Location:366411
      HTH_psq; helix-turn-helix, Psq domain
    7. XM_036164970.1XP_036020863.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

      Conserved Domains (1) summary
      pfam05225
      Location:442487
      HTH_psq; helix-turn-helix, Psq domain
    8. XM_036164969.1XP_036020862.1  ligand-dependent nuclear receptor corepressor-like protein isoform X3

      Conserved Domains (1) summary
      pfam05225
      Location:455500
      HTH_psq; helix-turn-helix, Psq domain
    9. XM_030254345.2XP_030110205.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

      UniProtKB/TrEMBL
      A0A0H2UH31
    10. XM_030254343.2XP_030110203.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

    11. XM_030254344.1XP_030110204.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

    RNA

    1. XR_004942478.1 RNA Sequence

    2. XR_004942488.1 RNA Sequence

    3. XR_004942487.1 RNA Sequence

    4. XR_004942483.1 RNA Sequence

    5. XR_004942479.1 RNA Sequence

    6. XR_004942482.1 RNA Sequence

    7. XR_004942481.1 RNA Sequence

    8. XR_004942484.1 RNA Sequence

    9. XR_004942480.1 RNA Sequence

    10. XR_004942485.1 RNA Sequence