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    Ube2o ubiquitin-conjugating enzyme E2O [ Mus musculus (house mouse) ]

    Gene ID: 217342, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2oprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Oprovided by MGI
    Primary source
    MGI:MGI:2444266
    See related
    Ensembl:ENSMUSG00000020802 AllianceGenome:MGI:2444266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E2-230K; mKIAA1734; 9630022H21; B230113M03Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of BMP signaling pathway; protein ubiquitination; and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasm and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; genitourinary system; and immune system. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 21.5), liver E14.5 (RPKM 19.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube2o in Genome Data Viewer
    Location:
    11 E2; 11 81.42 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116428500..116472281, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116537740..116581503, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 1 Neighboring gene sphingosine kinase 1 Neighboring gene STARR-seq mESC enhancer starr_31212 Neighboring gene arylalkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene STARR-seq mESC enhancer starr_31215 Neighboring gene STARR-seq mESC enhancer starr_31216 Neighboring gene cytoglobin Neighboring gene photoreceptor disc component

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O
    Names
    E2/E3 hybrid ubiquitin-protein ligase UBE2O
    ubiquitin carrier protein O
    ubiquitin-conjugating enzyme E2 of 230 kDa
    ubiquitin-conjugating enzyme E2-230K
    ubiquitin-protein ligase O
    ubiquitinating enzyme E2-230 kDa
    NP_001414250.1
    NP_776116.2
    XP_011247262.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427321.1NP_001414250.1  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL607039, AL645851
    2. NM_173755.4NP_776116.2  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607039, AL645851
      Consensus CDS
      CCDS25670.1
      UniProtKB/Swiss-Prot
      A2A7X3, Q60800, Q6PCR9, Q6ZPJ3, Q7TPN2, Q8BLE8
      Related
      ENSMUSP00000080791.5, ENSMUST00000082152.5
      Conserved Domains (1) summary
      cd00195
      Location:9551105
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116428500..116472281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248960.1XP_011247262.1  (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X2

      Related
      ENSMUST00000134102.2
      Conserved Domains (1) summary
      cd00195
      Location:398548
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...