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    Cerk ceramide kinase [ Mus musculus (house mouse) ]

    Gene ID: 223753, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cerkprovided by MGI
    Official Full Name
    ceramide kinaseprovided by MGI
    Primary source
    MGI:MGI:2386052
    See related
    Ensembl:ENSMUSG00000035891 AllianceGenome:MGI:2386052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1646; D330016D08Rik
    Summary
    Enables ceramide kinase activity. Predicted to be involved in ceramide metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 55.0), cerebellum adult (RPKM 36.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cerk in Genome Data Viewer
    Location:
    15 E2; 15 40.52 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (86023302..86070537, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (86139101..86186259, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41375 Neighboring gene STARR-seq mESC enhancer starr_39412 Neighboring gene GRAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E9422 Neighboring gene predicted gene 15722 Neighboring gene STARR-positive B cell enhancer mm9_chr15:86003680-86003981 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86012285-86012732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86013160-86013361 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86033071-86033180 Neighboring gene RIKEN cDNA 2810001A02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7404 Neighboring gene predicted gene 15569 Neighboring gene TBC1 domain family, member 22a Neighboring gene predicted gene, 22818

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ceramide kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ceramide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables ceramide kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ceramide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ceramide kinase
    Names
    acylsphingosine kinase
    mCERK
    NP_663450.3
    XP_011243890.1
    XP_030104368.1
    XP_030104369.1
    XP_036015253.1
    XP_036015254.1
    XP_036015255.1
    XP_036015256.1
    XP_036015257.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145475.4NP_663450.3  ceramide kinase

      See identical proteins and their annotated locations for NP_663450.3

      Status: VALIDATED

      Source sequence(s)
      AC116764, AK042077, AK052269, BU756835
      Consensus CDS
      CCDS27728.1
      UniProtKB/Swiss-Prot
      Q52KP2, Q8K4Q7
      Related
      ENSMUSP00000038203.10, ENSMUST00000044332.16
      Conserved Domains (1) summary
      PLN02204
      Location:84528
      PLN02204; diacylglycerol kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      86023302..86070537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159362.1XP_036015255.1  ceramide kinase isoform X4

      UniProtKB/TrEMBL
      Q6ZPK5
      Related
      ENSMUST00000150767.8
      Conserved Domains (1) summary
      cl01255
      Location:7451
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_011245588.4XP_011243890.1  ceramide kinase isoform X3

      Conserved Domains (1) summary
      PLN02204
      Location:84477
      PLN02204; diacylglycerol kinase
    3. XM_030248509.2XP_030104369.1  ceramide kinase isoform X8

      Conserved Domains (1) summary
      cl01255
      Location:20279
      DAGK_cat; Diacylglycerol kinase catalytic domain
    4. XM_030248508.2XP_030104368.1  ceramide kinase isoform X7

      UniProtKB/TrEMBL
      Q6ZPK5
      Conserved Domains (1) summary
      PLN02204
      Location:20330
      PLN02204; diacylglycerol kinase
    5. XM_036159361.1XP_036015254.1  ceramide kinase isoform X2

      Conserved Domains (1) summary
      cl01255
      Location:84415
      DAGK_cat; Diacylglycerol kinase catalytic domain
    6. XM_036159363.1XP_036015256.1  ceramide kinase isoform X5

      Conserved Domains (1) summary
      cl01255
      Location:20268
      DAGK_cat; Diacylglycerol kinase catalytic domain
    7. XM_036159360.1XP_036015253.1  ceramide kinase isoform X1

      Conserved Domains (1) summary
      cl01255
      Location:84466
      DAGK_cat; Diacylglycerol kinase catalytic domain
    8. XM_036159364.1XP_036015257.1  ceramide kinase isoform X6

      Conserved Domains (1) summary
      cl01255
      Location:84331
      DAGK_cat; Diacylglycerol kinase catalytic domain