U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Shc2 SHC (Src homology 2 domain containing) transforming protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 216148, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shc2provided by MGI
    Official Full Name
    SHC (Src homology 2 domain containing) transforming protein 2provided by MGI
    Primary source
    MGI:MGI:106180
    See related
    Ensembl:ENSMUSG00000020312 AllianceGenome:MGI:106180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCK; Sli; ShcB; 6720466E06
    Summary
    Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; sensory organ; skeleton; and skin. Orthologous to human SHC2 (SHC adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 14.0), whole brain E14.5 (RPKM 11.3) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Shc2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79453768..79473752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79617934..79637918, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule associated protein 2 Neighboring gene predicted gene, 51808 Neighboring gene C2 calcium-dependent domain containing 4C Neighboring gene CIMAP1 family member D Neighboring gene mucosal vascular addressin cell adhesion molecule 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SHC-transforming protein 2
    Names
    SH2 domain protein C2
    SHC-transforming protein B
    protein Sck
    protein Sli
    src homology 2 domain-containing-transforming protein C2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024539.1NP_001019710.1  SHC-transforming protein 2

      See identical proteins and their annotated locations for NP_001019710.1

      Status: VALIDATED

      Source sequence(s)
      AK032878, BB646065, BC059866
      Consensus CDS
      CCDS48620.1
      UniProtKB/Swiss-Prot
      Q8BMC3
      Related
      ENSMUSP00000020564.7, ENSMUST00000020564.7
      Conserved Domains (2) summary
      cd09925
      Location:470573
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:116285
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79453768..79473752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)