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    Dgki diacylglycerol kinase, iota [ Mus musculus (house mouse) ]

    Gene ID: 320127, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dgkiprovided by MGI
    Official Full Name
    diacylglycerol kinase, iotaprovided by MGI
    Primary source
    MGI:MGI:2443430
    See related
    Ensembl:ENSMUSG00000038665 AllianceGenome:MGI:2443430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430604M11Rik; C130010K08Rik
    Summary
    Enables ATP-dependent diacylglycerol kinase activity; GTPase inhibitor activity; and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dgki in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (36814316..37281034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (36837381..37300955, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15571 Neighboring gene predicted gene 2189 Neighboring gene STARR-seq mESC enhancer starr_15572 Neighboring gene pleiotrophin Neighboring gene predicted gene, 53282 Neighboring gene STARR-seq mESC enhancer starr_15573 Neighboring gene predicted gene, 52857 Neighboring gene STARR-seq mESC enhancer starr_15575 Neighboring gene predicted pseudogene 7452 Neighboring gene STARR-seq mESC enhancer starr_15579 Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:37392120-37392421 Neighboring gene predicted gene, 33275 Neighboring gene predicted gene, 33318

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in extrinsic component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase iota
    Names
    DAG kinase iota
    NP_001074675.1
    NP_001334033.1
    XP_006506321.1
    XP_006506322.1
    XP_011239687.1
    XP_017177113.1
    XP_017177114.1
    XP_017177115.1
    XP_017177116.1
    XP_017177117.1
    XP_017177118.1
    XP_017177119.1
    XP_017177121.1
    XP_017177122.1
    XP_030111313.1
    XP_030111314.1
    XP_036022113.1
    XP_036022114.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081206.2NP_001074675.1  diacylglycerol kinase iota isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154019, AC159480, AK081360
      Consensus CDS
      CCDS39459.1
      UniProtKB/Swiss-Prot
      D3YWQ0, D3Z2W1
      UniProtKB/TrEMBL
      D3Z519
      Related
      ENSMUSP00000099071.4, ENSMUST00000101532.10
      Conserved Domains (7) summary
      smart00045
      Location:521678
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:373494
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8691068
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:966997
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:9361031
      Ank_2; Ankyrin repeats (3 copies)
      cd20850
      Location:163235
      C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
      cd20896
      Location:244318
      C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
    2. NM_001347104.2NP_001334033.1  diacylglycerol kinase iota isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114574, AC154019, AC159480, AC184160
      Consensus CDS
      CCDS85032.1
      UniProtKB/TrEMBL
      D3Z519
      Related
      ENSMUSP00000087788.5, ENSMUST00000090314.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      36814316..37281034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506259.5XP_006506322.1  diacylglycerol kinase iota isoform X8

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:516673
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:368489
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8641063
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:961992
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9311026
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_011241385.4XP_011239687.1  diacylglycerol kinase iota isoform X16

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:520677
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:372493
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8321031
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:929960
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:899994
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_006506258.5XP_006506321.1  diacylglycerol kinase iota isoform X7

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:520677
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:372493
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8681067
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:965996
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9351030
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_030255453.2XP_030111313.1  diacylglycerol kinase iota isoform X9

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:521678
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:373494
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8541053
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:951982
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9211016
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_017321628.3XP_017177117.1  diacylglycerol kinase iota isoform X5

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:561718
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:413534
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8881087
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:9851016
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9551050
      Ank_2; Ankyrin repeats (3 copies)
    6. XM_017321625.3XP_017177114.1  diacylglycerol kinase iota isoform X2

      Conserved Domains (6) summary
      smart00045
      Location:561718
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:413534
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:9091108
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:10061037
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9761071
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_017321629.3XP_017177118.1  diacylglycerol kinase iota isoform X6

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8741073
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:9711002
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9411036
      Ank_2; Ankyrin repeats (3 copies)
    8. XM_017321627.3XP_017177116.1  diacylglycerol kinase iota isoform X4

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8891088
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:9861017
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9561051
      Ank_2; Ankyrin repeats (3 copies)
    9. XM_017321626.3XP_017177115.1  diacylglycerol kinase iota isoform X3

      Conserved Domains (6) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:8951094
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:9921023
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9621057
      Ank_2; Ankyrin repeats (3 copies)
    10. XM_017321624.3XP_017177113.1  diacylglycerol kinase iota isoform X1

      Conserved Domains (6) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:9101109
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:10071038
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:9771072
      Ank_2; Ankyrin repeats (3 copies)
    11. XM_036166220.1XP_036022113.1  diacylglycerol kinase iota isoform X13

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:226383
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:78199
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:574773
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:671702
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:641736
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:123
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    12. XM_036166221.1XP_036022114.1  diacylglycerol kinase iota isoform X14

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (5) summary
      smart00045
      Location:196353
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:48169
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:544743
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:641672
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:611706
      Ank_2; Ankyrin repeats (3 copies)
    13. XM_030255454.2XP_030111314.1  diacylglycerol kinase iota isoform X12

      UniProtKB/TrEMBL
      S4R2G0
      Conserved Domains (3) summary
      smart00045
      Location:516673
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:368489
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    14. XM_017321632.3XP_017177121.1  diacylglycerol kinase iota isoform X11

      UniProtKB/TrEMBL
      S4R2G0
      Conserved Domains (3) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    15. XM_017321630.3XP_017177119.1  diacylglycerol kinase iota isoform X10

      UniProtKB/TrEMBL
      S4R2G0
      Related
      ENSMUSP00000138628.2, ENSMUST00000138286.8
      Conserved Domains (3) summary
      smart00045
      Location:562719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    16. XM_017321633.3XP_017177122.1  diacylglycerol kinase iota isoform X15

      UniProtKB/TrEMBL
      S4R215
      Related
      ENSMUSP00000138457.2, ENSMUST00000150300.9
      Conserved Domains (3) summary
      smart00046
      Location:414535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl02440
      Location:562624
      DAGK_acc; Diacylglycerol kinase accessory domain

    RNA

    1. XR_004942967.1 RNA Sequence

    2. XR_004942966.1 RNA Sequence