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    Zbed6 zinc finger, BED type containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 667118, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zbed6provided by MGI
    Official Full Name
    zinc finger, BED type containing 6provided by MGI
    Primary source
    MGI:MGI:3828086
    See related
    Ensembl:ENSMUSG00000094410 AllianceGenome:MGI:3828086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MGR; Gm8466; Gm38394
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of muscle cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within blastocyst hatching. Located in cytoplasm and nucleolus. Is expressed in early conceptus; nervous system; neural retina; and secondary oocyte. Orthologous to human ZBED6 (zinc finger BED-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Zbed6 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133547606..133589112, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133655879..133660885, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene predicted gene, 23939 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene lymphocyte transmembrane adaptor 1 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene microRNA 6903

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger BED domain-containing protein 6
    Names
    muscle growth regulator
    zinc finger, BED domain containing 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166552.2NP_001160024.1  zinc finger BED domain-containing protein 6

      See identical proteins and their annotated locations for NP_001160024.1

      Status: VALIDATED

      Source sequence(s)
      AC124338
      Consensus CDS
      CCDS56643.1
      UniProtKB/Swiss-Prot
      D2EAC2, D2EAC3, Q3UMD3, Q8C1U4, Q8CBM9
      UniProtKB/TrEMBL
      G0LE24
      Conserved Domains (2) summary
      smart00614
      Location:135182
      ZnF_BED; BED zinc finger
      pfam05699
      Location:870950
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region
    2. NM_001395904.1NP_001382833.1  zinc finger BED domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      AC124338
      UniProtKB/Swiss-Prot
      D2EAC2, D2EAC3, Q3UMD3, Q8C1U4, Q8CBM9
      UniProtKB/TrEMBL
      G0LE24
      Related
      ENSMUSP00000136026.2, ENSMUST00000179598.4
      Conserved Domains (2) summary
      smart00614
      Location:135182
      ZnF_BED; BED zinc finger
      pfam05699
      Location:870950
      Dimer_Tnp_hAT; hAT family C-terminal dimerization region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133547606..133589112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)