Lrp1 low density lipoprotein receptor-related protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrp1provided by MGI
Official Full Name: low density lipoprotein receptor-related protein 1provided by MGI
Primary source: MGI:MGI:96828
See related: Ensembl:ENSMUSG00000040249 AllianceGenome:MGI:96828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lrp; A2mr; CD91; b2b1554Clo
Summary: Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and negative regulation of Wnt signaling pathway. Located in external side of plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 53.9), liver adult (RPKM 50.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.52 cM

Exon count:: 90

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127374026..127457158, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127538157..127621148, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.
Title: Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.
Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding.
Title: Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's disease mice: Potential role in chronic heavy alcohol feeding.
LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.
Title: LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.
LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes.
Title: LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes.
LRP1 in GABAergic neurons is a key link between obesity and memory function.
Title: LRP1 in GABAergic neurons is a key link between obesity and memory function.
LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation.
Title: LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation.
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
Title: ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.
Title: Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.
Thymosin beta4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
Title: Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.
Title: LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.

Submit: New GeneRIF Correction See all GeneRIFs (236)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225342

RH132158 (e-PCR)
- UniSTS:215441

Lrp1 (e-PCR), detects polymorphism
- UniSTS:471189

RH136136 (e-PCR)
- UniSTS:210131

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-2 macroglobulin receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha-2 macroglobulin receptor activity	ISO Inferred from Sequence Orthology more info
enables alpha-2 macroglobulin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cargo receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cargo receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables clathrin heavy chain binding	IEA Inferred from Electronic Annotation more info
enables clathrin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by cellular catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by cellular catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by transcytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance by transcytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta clearance by transcytosis	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte activation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardiac septum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemoattraction of axon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysosomal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension involved in regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collateral sprouting of injured axon	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phospholipase A2 activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pulmonary blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transport across blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: prolow-density lipoprotein receptor-related protein 1

Names: LRP-1; alpha 2-macroglobulin receptor; lipoprotein receptor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008512.2 → NP_032538.2 prolow-density lipoprotein receptor-related protein 1 precursor

See identical proteins and their annotated locations for NP_032538.2

Status: VALIDATED

Source sequence(s)

AC167719, AF367720, AK078273, AK154429, BU615020, CA888999, CB527265, CF535491, X67469

Consensus CDS

CCDS24245.1

UniProtKB/Swiss-Prot

Q61291, Q91ZX7, Q920Y4

UniProtKB/TrEMBL

A0A0R4J0I9

Related

ENSMUSP00000044004.9, ENSMUST00000049149.15

Conserved Domains (8) summary

smart00192
Location:3494 → 3527

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3095 → 3137

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:2983 → 3012

EGF_CA; Calcium-binding EGF-like domain

COG3386
Location:2254 → 2464

YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]

cd00112
Location:3576 → 3610

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:4014 → 4054

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam12662
Location:2963 → 2986

cEGF; Complement Clr-like EGF-like

pfam14670
Location:808 → 843

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

127374026..127457158 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155650.1 → XP_036011543.1 prolow-density lipoprotein receptor-related protein 1 isoform X1

UniProtKB/Swiss-Prot

Q61291, Q91ZX7, Q920Y4

Conserved Domains (8) summary

smart00192
Location:3511 → 3544

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:3112 → 3154

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:3000 → 3029

EGF_CA; Calcium-binding EGF-like domain

COG3386
Location:2271 → 2481

YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]

cd00112
Location:3593 → 3627

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:4031 → 4071

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam12662
Location:2980 → 3003

cEGF; Complement Clr-like EGF-like

pfam14670
Location:808 → 843

FXa_inhibition; Coagulation Factor Xa inhibitory site