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    Rbp1 retinol binding protein 1, cellular [ Mus musculus (house mouse) ]

    Gene ID: 19659, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbp1provided by MGI
    Official Full Name
    retinol binding protein 1, cellularprovided by MGI
    Primary source
    MGI:MGI:97876
    See related
    Ensembl:ENSMUSG00000046402 AllianceGenome:MGI:97876
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crbp; CRBPI; Rbp-1
    Summary
    Predicted to enable all-trans-retinol binding activity and fatty acid binding activity. Acts upstream of or within regulation of granulocyte differentiation; response to vitamin A; and retinoid metabolic process. Located in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 52.2), liver E18 (RPKM 35.5) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Rbp1 in Genome Data Viewer
    Location:
    9 E3.3; 9 51.36 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (98305014..98328604)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (98422961..98446551)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10579 Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene predicted gene, 46126 Neighboring gene predicted gene 28530 Neighboring gene retinol binding protein 2, cellular Neighboring gene RIKEN cDNA 4930579K19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3853

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables all-trans-retinol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables all-trans-retinol binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables all-trans-retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables all-trans-retinol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of location in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to benzoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to vitamin A IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinoic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within retinoic acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin A metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin A metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    retinol-binding protein 1
    Names
    CRBP-I
    cellular retinol-binding protein I
    mCRBPI
    NP_035384.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011254.5NP_035384.1  retinol-binding protein 1

      See identical proteins and their annotated locations for NP_035384.1

      Status: PROVISIONAL

      Source sequence(s)
      AC117214, AC144809
      Consensus CDS
      CCDS23424.1
      UniProtKB/Swiss-Prot
      Q00915
      UniProtKB/TrEMBL
      Q58EU7
      Related
      ENSMUSP00000059749.10, ENSMUST00000052068.11
      Conserved Domains (1) summary
      pfam00061
      Location:6134
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      98305014..98328604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)