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    Ces1g carboxylesterase 1G [ Mus musculus (house mouse) ]

    Gene ID: 12623, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ces1gprovided by MGI
    Official Full Name
    carboxylesterase 1Gprovided by MGI
    Primary source
    MGI:MGI:88378
    See related
    Ensembl:ENSMUSG00000057074 AllianceGenome:MGI:88378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CEH; Ces1; Ces-1; Ses-1
    Summary
    This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in liver adult (RPKM 42.5), colon adult (RPKM 3.1) and 1 other tissue See more
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    Genomic context

    See Ces1g in Genome Data Viewer
    Location:
    8 C5; 8 45.29 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94028997..94063837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93302369..93337209, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1F Neighboring gene STARR-seq mESC enhancer starr_22334 Neighboring gene carboxylesterase 1H Neighboring gene STARR-seq mESC enhancer starr_22335 Neighboring gene predicted gene, 30132

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sterol ester esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within chylomicron assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bile acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bile acid secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of chylomicron remnant clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    liver carboxylesterase 1
    Names
    ES-x
    acyl-coenzyme A:cholesterol acyltransferase
    carboxylesterase 1
    cholesteryl ester hydrolase
    NP_067431.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021456.4NP_067431.2  liver carboxylesterase 1 precursor

      See identical proteins and their annotated locations for NP_067431.2

      Status: REVIEWED

      Source sequence(s)
      AI316467, AK136588
      Consensus CDS
      CCDS22531.1
      UniProtKB/Swiss-Prot
      O55136, Q8VCC2
      UniProtKB/TrEMBL
      Q3UW56
      Related
      ENSMUSP00000037555.8, ENSMUST00000044602.8
      Conserved Domains (2) summary
      COG0657
      Location:121239
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:24545
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94028997..94063837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)