Leprot leptin receptor overlapping transcript [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Leprotprovided by MGI
Official Full Name: leptin receptor overlapping transcriptprovided by MGI
Primary source: MGI:MGI:2687005
See related: Ensembl:ENSMUSG00000035212 AllianceGenome:MGI:2687005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LEPR; VPS55; Endo1`; Obrgrp; OB-RGRP; Endospanin1
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway; negative regulation of protein localization to cell surface; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus. Predicted to be active in endosome. Is expressed in central nervous system; heart valve; and retina nuclear layer. Orthologous to human LEPROT (leptin receptor overlapping transcript). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 58.2), lung adult (RPKM 39.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 46.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (101504922..101516561)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (101647783..101659364)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations.
Title: Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations.
both LEPROT and LEPROTL1 expression were regulated in liver by physiologic and pathologic changes in glucose homeostasis
Title: LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leptin receptor gene-related protein

Names: OB-R gene-related protein; endospanin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419413.1 → NP_001406342.1 leptin receptor gene-related protein isoform 2

Status: VALIDATED

Source sequence(s)

AL929373, BX323551

Related

ENSMUSP00000102540.2, ENSMUST00000106927.2
NM_175036.5 → NP_778201.1 leptin receptor gene-related protein isoform 1

Status: VALIDATED

Source sequence(s)

AL929373, BX323551

Consensus CDS

CCDS18396.1

UniProtKB/Swiss-Prot

A2AV64, O89013, Q3TGT4, Q3TWZ2, Q545G9, Q91Z23

Related

ENSMUSP00000030254.9, ENSMUST00000030254.15

Conserved Domains (1) summary

pfam04133
Location:7 → 124

Vps55; Vacuolar protein sorting 55