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    Kpna4 karyopherin subunit alpha 4 [ Mus musculus (house mouse) ]

    Gene ID: 16649, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kpna4provided by MGI
    Official Full Name
    karyopherin subunit alpha 4provided by MGI
    Primary source
    MGI:MGI:1100848
    See related
    Ensembl:ENSMUSG00000027782 AllianceGenome:MGI:1100848
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    qip1; IPOA3; 1110058D08Rik
    Summary
    Enables nuclear import signal receptor activity. Acts upstream of or within protein import into nucleus and response to hydrogen peroxide. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.2), CNS E11.5 (RPKM 14.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Kpna4 in Genome Data Viewer
    Location:
    3 E1; 3 32.18 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68979554..69034425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69072221..69127092, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 59 Neighboring gene RIKEN cDNA 9630025H16 gene Neighboring gene predicted gene, 22009 Neighboring gene STARR-positive B cell enhancer ABC_E651 Neighboring gene predicted gene 1647 Neighboring gene STARR-seq mESC enhancer starr_07919 Neighboring gene predicted gene, 54203

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    importin subunit alpha-3
    Names
    importin alpha 3
    importin alpha Q1
    importin subunit alpha-4
    karyopherin (importin) alpha 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008467.4NP_032493.1  importin subunit alpha-3

      See identical proteins and their annotated locations for NP_032493.1

      Status: PROVISIONAL

      Source sequence(s)
      AC119847
      Consensus CDS
      CCDS17403.1
      UniProtKB/Swiss-Prot
      O35343
      UniProtKB/TrEMBL
      Q3UGH8, Q4FJX1
      Related
      ENSMUSP00000141227.2, ENSMUST00000194558.6
      Conserved Domains (2) summary
      COG5064
      Location:11513
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:279311
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      68979554..69034425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)