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    Clec1a C-type lectin domain family 1, member a [ Mus musculus (house mouse) ]

    Gene ID: 243653, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clec1aprovided by MGI
    Official Full Name
    C-type lectin domain family 1, member aprovided by MGI
    Primary source
    MGI:MGI:2444151
    See related
    Ensembl:ENSMUSG00000033082 AllianceGenome:MGI:2444151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5930406N14Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gut; heart ventricle; and lung. Human ortholog(s) of this gene implicated in aspergillosis. Orthologous to human CLEC1A (C-type lectin domain family 1 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 14.8), ovary adult (RPKM 2.0) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Clec1a in Genome Data Viewer
    Location:
    6 F3; 6 63.32 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129403647..129428963, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129426684..129452000, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12, member B Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene STARR-seq mESC enhancer starr_17480 Neighboring gene predicted gene, 45969 Neighboring gene C-type lectin domain family 7, member a Neighboring gene oxidized low density lipoprotein (lectin-like) receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    C-type lectin domain family 1 member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347475.1NP_001334404.1  C-type lectin domain family 1 member A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate frame-shifting splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1
      Source sequence(s)
      AC138620, AK031121, AK036846, BC052840, BX512526
      Consensus CDS
      CCDS85169.1
      UniProtKB/TrEMBL
      A0A0N4SV03, Q8BZ31
      Related
      ENSMUSP00000144896.2, ENSMUST00000203162.3
    2. NM_175526.3NP_780735.2  C-type lectin domain family 1 member A isoform 1

      See identical proteins and their annotated locations for NP_780735.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC138620, AK049608, BX512526
      Consensus CDS
      CCDS20587.1
      UniProtKB/Swiss-Prot
      Q7TPX7, Q8BMH5, Q8BWY2
      Related
      ENSMUSP00000047065.8, ENSMUST00000037481.10
      Conserved Domains (1) summary
      cd03593
      Location:136258
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129403647..129428963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)