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    Sp110 Sp110 nuclear body protein [ Mus musculus (house mouse) ]

    Gene ID: 109032, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sp110provided by MGI
    Official Full Name
    Sp110 nuclear body proteinprovided by MGI
    Primary source
    MGI:MGI:1923364
    See related
    Ensembl:ENSMUSG00000070034 AllianceGenome:MGI:1923364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ipr1; 52kDa; Ifi75; 5031415C07Rik; 5830484A20Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within positive regulation of apoptotic process and response to bacterium. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and thymus primordium. Human ortholog(s) of this gene implicated in hepatic venoocclusive disease with immunodeficiency and tuberculosis. Orthologous to human SP110 (SP110 nuclear body protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 21.8), spleen adult (RPKM 17.2) and 14 other tissues See more
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    Genomic context

    See Sp110 in Genome Data Viewer
    Location:
    1 C5; 1 43.6 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85498462..85538571, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85570735..85610850, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7592 Neighboring gene predicted gene 7281 Neighboring gene STARR-seq mESC enhancer starr_01546 Neighboring gene STARR-seq mESC enhancer starr_01547 Neighboring gene predicted gene 2666 Neighboring gene STARR-seq mESC enhancer starr_01548 Neighboring gene predicted gene 2427 Neighboring gene STARR-positive B cell enhancer mm9_chr1:87441371-87441672 Neighboring gene STARR-seq mESC enhancer starr_01549 Neighboring gene Sp140 nuclear body protein Neighboring gene STARR-seq mESC enhancer starr_01550 Neighboring gene STARR-seq mESC enhancer starr_01551 Neighboring gene nuclear antigen Sp100 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87584047-87584232 Neighboring gene STARR-positive B cell enhancer ABC_E1221 Neighboring gene STARR-positive B cell enhancer ABC_E323 Neighboring gene RIKEN cDNA A630001G21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87629249-87629446 Neighboring gene STARR-positive B cell enhancer ABC_E1551

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC118608

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sp110 nuclear body protein
    Names
    interferon-induced protein 75, 52kD
    intracellular pathogen resistance 1
    intracellular pathogen resistance protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030194.1NP_084470.1  sp110 nuclear body protein

      See identical proteins and their annotated locations for NP_084470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK019873, AK077800, BF662066, BY234698
      Consensus CDS
      CCDS35637.1
      UniProtKB/Swiss-Prot
      Q05D41, Q3UCV7, Q80V00, Q8BVK9
      Related
      ENSMUSP00000091226.7, ENSMUST00000093508.7
      Conserved Domains (2) summary
      pfam01342
      Location:359432
      SAND; SAND domain
      pfam03172
      Location:11105
      Sp100; Sp100 domain
    2. NM_175397.4NP_780606.3  sp110 nuclear body protein

      See identical proteins and their annotated locations for NP_780606.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK077800, AK150373, BF662066, CJ077357
      Consensus CDS
      CCDS35637.1
      UniProtKB/Swiss-Prot
      Q05D41, Q3UCV7, Q80V00, Q8BVK9
      Conserved Domains (2) summary
      pfam01342
      Location:359432
      SAND; SAND domain
      pfam03172
      Location:11105
      Sp100; Sp100 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85498462..85538571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247901.4XP_011246203.1  sp110 nuclear body protein isoform X4

      Conserved Domains (1) summary
      pfam03172
      Location:8106
      HSR; HSR domain
    2. XM_011247899.3XP_011246201.1  sp110 nuclear body protein isoform X2

      Conserved Domains (2) summary
      pfam01342
      Location:360433
      SAND; SAND domain
      pfam03172
      Location:8106
      HSR; HSR domain
    3. XM_011247900.3XP_011246202.1  sp110 nuclear body protein isoform X3

      Conserved Domains (2) summary
      pfam03172
      Location:8106
      HSR; HSR domain
      cl02536
      Location:363384
      SAND; SAND domain
    4. XM_006529069.3XP_006529132.1  sp110 nuclear body protein isoform X1

      See identical proteins and their annotated locations for XP_006529132.1

      Conserved Domains (2) summary
      pfam01342
      Location:363436
      SAND; SAND domain
      pfam03172
      Location:8106
      HSR; HSR domain
    5. XM_011247897.3XP_011246199.1  sp110 nuclear body protein isoform X1

      See identical proteins and their annotated locations for XP_011246199.1

      Conserved Domains (2) summary
      pfam01342
      Location:363436
      SAND; SAND domain
      pfam03172
      Location:8106
      HSR; HSR domain
    6. XM_011247898.4XP_011246200.1  sp110 nuclear body protein isoform X1

      See identical proteins and their annotated locations for XP_011246200.1

      Conserved Domains (2) summary
      pfam01342
      Location:363436
      SAND; SAND domain
      pfam03172
      Location:8106
      HSR; HSR domain
    7. XM_030255685.1XP_030111545.1  sp110 nuclear body protein isoform X1

      Conserved Domains (2) summary
      pfam01342
      Location:363436
      SAND; SAND domain
      pfam03172
      Location:8106
      HSR; HSR domain