U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gnl3l guanine nucleotide binding protein nucleolar 3 like [ Mus musculus (house mouse) ]

    Gene ID: 237107, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gnl3lprovided by MGI
    Official Full Name
    guanine nucleotide binding protein nucleolar 3 likeprovided by MGI
    Primary source
    MGI:MGI:2448557
    See related
    Ensembl:ENSMUSG00000025266 AllianceGenome:MGI:2448557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 22.1), frontal lobe adult (RPKM 21.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gnl3l in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149766129..149800318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150983133..151017322, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54086 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8765 Neighboring gene STARR-seq mESC enhancer starr_48075 Neighboring gene predicted gene, 46690 Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2 20S rRNA accumulation

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein-like 3-like protein
    Names
    guanine nucleotide binding protein-like 3 (nucleolar)-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168600.1NP_001162071.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_001162071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL805937, BY640210, CJ066167
      Consensus CDS
      CCDS41174.1
      UniProtKB/Swiss-Prot
      Q6PGG6
      Related
      ENSMUSP00000026297.6, ENSMUST00000026297.12
      Conserved Domains (3) summary
      PTZ00121
      Location:19166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]
    2. NM_198110.2NP_932778.1  guanine nucleotide-binding protein-like 3-like protein

      See identical proteins and their annotated locations for NP_932778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2)represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB644039, BC057033, BY640210
      Consensus CDS
      CCDS41174.1
      UniProtKB/Swiss-Prot
      Q6PGG6
      Related
      ENSMUSP00000108311.3, ENSMUST00000112691.9
      Conserved Domains (3) summary
      PTZ00121
      Location:19166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149766129..149800318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528805.5XP_006528868.1  guanine nucleotide-binding protein-like 3-like protein isoform X1

      See identical proteins and their annotated locations for XP_006528868.1

      UniProtKB/Swiss-Prot
      Q6PGG6
      Conserved Domains (3) summary
      PTZ00121
      Location:19166
      PTZ00121; MAEBL; Provisional
      cd04178
      Location:129301
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG0012
      Location:246384
      GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]