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    Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 102545, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cmtm7provided by MGI
    Official Full Name
    CKLF-like MARVEL transmembrane domain containing 7provided by MGI
    Primary source
    MGI:MGI:2447166
    See related
    Ensembl:ENSMUSG00000032436 AllianceGenome:MGI:2447166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LNV; Cklfsf7
    Summary
    Predicted to enable cytokine activity. Acts upstream of or within B-1a B cell differentiation. Predicted to be located in extracellular space. Predicted to be active in membrane. Is expressed in thymus primordium. Orthologous to human CMTM7 (CKLF like MARVEL transmembrane domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 190.5), stomach adult (RPKM 118.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cmtm7 in Genome Data Viewer
    Location:
    9 F3; 9 65.13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114585904..114611061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114756836..114781993, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 light intermediate chain 1 Neighboring gene STARR-seq mESC enhancer starr_25388 Neighboring gene STARR-positive B cell enhancer ABC_E2310 Neighboring gene CKLF-like MARVEL transmembrane domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114662028-114662553 Neighboring gene STARR-seq mESC enhancer starr_25390 Neighboring gene STARR-seq mESC enhancer starr_25391 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene predicted gene, 23889 Neighboring gene predicted gene, 30448

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells. Liu Z, et al. Cell Immunol, 2020 Jun. PMID 32305130
    2. Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage. Liu Z, et al. Int Immunol, 2019 Oct 16. PMID 31081901
    3. CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells. Liu Z, et al. Eur J Immunol, 2020 Jun. PMID 32022930
    4. A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells. Zhang Y, et al. Int Immunol, 2014 Jan. PMID 24080084
    5. Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor. Miyazaki A, et al. PLoS One, 2012. PMID 22363743, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igmu repertoire of splenic B-1a cells.
      Title: Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.
    2. CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
      Title: CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
    3. The Cmtm7 deficiency resulted in a slow proliferation and high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a cell development at the transitional stage.
      Title: Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage.
    4. The reduction of B-1a cells in Cmtm7(flox/) mice was associated with reduced BCR expression.
      Title: A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.
    5. CMTM7 functions to link sIgM and BLNK in the plasma membrane.
      Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B-1a B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 7
    Names
    chemokine-like factor super family 7
    chemokine-like factor superfamily member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252479.1 → NP_001239408.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001239408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA002761, AC163344, BC038633
      Consensus CDS
      CCDS57709.1
      UniProtKB/TrEMBL
      Q3THH0
      Related
      ENSMUSP00000081927.8, ENSMUST00000084867.9
      Conserved Domains (1) summary
      cl04571
      Location:32 → 119
      MARVEL; Membrane-associating domain

    2. NM_133978.2 → NP_598739.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_598739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC163344, AF188504
      Consensus CDS
      CCDS57710.1
      UniProtKB/Swiss-Prot
      Q8CHW2, Q9ESD6
      UniProtKB/TrEMBL
      Q3THH0
      Related
      ENSMUSP00000035009.9, ENSMUST00000035009.16
      Conserved Domains (1) summary
      pfam01284
      Location:32 → 152
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      114585904..114611061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESD6.1 GenPept UniProtKB/Swiss-Prot:Q9ESD6

    Gene LinkOut

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