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    Aida axin interactor, dorsalization associated [ Mus musculus (house mouse) ]

    Gene ID: 108909, updated on 9-Dec-2024

    Summary

    Official Symbol
    Aidaprovided by MGI
    Official Full Name
    axin interactor, dorsalization associatedprovided by MGI
    Primary source
    MGI:MGI:1919737
    See related
    Ensembl:ENSMUSG00000042901 AllianceGenome:MGI:1919737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610208M17Rik
    Summary
    Enables protein domain specific binding activity. Involved in negative regulation of JNK cascade and negative regulation of protein-containing complex assembly. Acts upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Located in cytoplasm. Orthologous to human AIDA (axin interactor, dorsalization associated). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: On Build 36, NM_181732.2 was annotated on chromosome 8 on the reference assembly, chromosome 1 on the Celera assembly, and unplaced on MGSCv3. On Build 37, all placements are on chromosome 1. [04 Sep 2007]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.5), limb E14.5 (RPKM 15.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Aida in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183078604..183105356)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183297060..183324501)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC6869, MGC101949

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in determination of ventral identity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within determination of ventral identity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JNK cascade IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of determination of dorsal identity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    axin interactor, dorsalization-associated protein
    Names
    axin interaction partner and dorsalization antagonist

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181732.4NP_859421.1  axin interactor, dorsalization-associated protein

      See identical proteins and their annotated locations for NP_859421.1

      Status: VALIDATED

      Source sequence(s)
      AK081494, BC086763, BY511767
      Consensus CDS
      CCDS56663.1
      UniProtKB/Swiss-Prot
      Q3U6V0, Q3UP85, Q6NXY2, Q6PG77, Q78W09, Q8C4Q6, Q99K80
      Related
      ENSMUSP00000104795.3, ENSMUST00000109166.8
      Conserved Domains (2) summary
      pfam08910
      Location:9112
      Aida_N; Aida N-terminus
      pfam14186
      Location:161299
      Aida_C2; Cytoskeletal adhesion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      183078604..183105356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145626.3: Suppressed sequence

      Description
      NM_145626.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.