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    Creg1 cellular repressor of E1A-stimulated genes 1 [ Mus musculus (house mouse) ]

    Gene ID: 433375, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Creg1provided by MGI
    Official Full Name
    cellular repressor of E1A-stimulated genes 1provided by MGI
    Primary source
    MGI:MGI:1344382
    See related
    Ensembl:ENSMUSG00000040713 AllianceGenome:MGI:1344382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Creg
    Summary
    Predicted to enable insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including autophagy; lysosomal lumen acidification; and regulation of DNA-templated transcription. Located in endosome and lysosome. Part of transcription regulator complex. Is expressed in central nervous system; liver; and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 225.0), liver adult (RPKM 174.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Creg1 in Genome Data Viewer
    Location:
    1 H2.3; 1 73.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165591327..165602878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165763758..165775309)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02911 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167591001-167591302 Neighboring gene RCSD domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167636283-167636436 Neighboring gene STARR-positive B cell enhancer ABC_E11104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167648574-167648683 Neighboring gene predicted gene, 51752 Neighboring gene STARR-positive B cell enhancer ABC_E1572 Neighboring gene STARR-positive B cell enhancer ABC_E4374 Neighboring gene STARR-positive B cell enhancer ABC_E7771 Neighboring gene STARR-positive B cell enhancer ABC_E9064 Neighboring gene CD247 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167732146-167732347 Neighboring gene predicted gene, 23402 Neighboring gene STARR-seq mESC enhancer starr_02912 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167775596-167775783 Neighboring gene predicted gene, 32999

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway. Zeng S, et al. Mol Neurobiol, 2023 Oct. PMID 37402034
    2. CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells. Goto A, et al. Biochem Biophys Res Commun, 2023 Jan 22. PMID 36528955
    3. Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. Wu M, et al. Int J Biol Sci, 2022. PMID 35280676, Free PMC Article
    4. Secreted CREG inhibits cell proliferation mediated by mannose 6-phosphate/insulin-like growth factor II receptor in NIH3T3 fibroblasts. Han YL, et al. Genes Cells, 2008 Sep. PMID 18691225
    5. Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice. Hashimoto M, et al. Int J Mol Sci, 2021 Jan 28. PMID 33525404, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration.
      Title: CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration.
    2. The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
      Title: The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
    3. CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway.
      Title: CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway.
    4. The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.
      Title: The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.
    5. CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells.
      Title: CREG1 stimulates AMPK phosphorylation and glucose uptake in skeletal muscle cells.
    6. CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
      Title: CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
    7. Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.
      Title: Effects of CREG1 on Age-Associated Metabolic Phenotypes and Renal Senescence in Mice.
    8. The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
      Title: The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.
    9. findings demonstrate that CREG1 stimulates brown adipocyte formation and browning, ameliorating obesity and its related pathology in vivo.
      Title: CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice.
    10. effect of CREG1 on Ucp1 promoter activity was also stimulated by retinoic acid. These results strongly suggest that CREG1 plays an important role on the regulation of UCP1 expression and brown adipogenesis
      Title: CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lysosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein CREG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011804.3 → NP_035934.1  protein CREG1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124587, AW495378
      Consensus CDS
      CCDS35759.1
      UniProtKB/Swiss-Prot
      O88668, Q3UNP8, Q8C3I1
      Related
      ENSMUSP00000107060.4, ENSMUST00000111432.10
      Conserved Domains (1) summary
      pfam13883
      Location:50 → 216
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    RNA

    1. NR_149310.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124587, AK150006, AW495378
      Related
      ENSMUST00000140769.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165591327..165602878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88668.1 GenPept UniProtKB/Swiss-Prot:O88668

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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