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    Zfp276 zinc finger protein (C2H2 type) 276 [ Mus musculus (house mouse) ]

    Gene ID: 57247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp276provided by MGI
    Official Full Name
    zinc finger protein (C2H2 type) 276provided by MGI
    Primary source
    MGI:MGI:1888495
    See related
    Ensembl:ENSMUSG00000001065 AllianceGenome:MGI:1888495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf276; D8Ertd370e; D8Ertd377e
    Summary
    Predicted to enable chromatin insulator sequence binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in kinetochore. Is expressed in several structures, including genitourinary system; liver; nervous system; sensory organ; and spleen. Orthologous to human ZNF276 (zinc finger protein 276). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.1), ovary adult (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp276 in Genome Data Viewer
    Location:
    8 E1; 8 72.09 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123980934..123997290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123254195..123270551)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933417D19 gene Neighboring gene cyclin dependent kinase 10 Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1 Neighboring gene Fanconi anemia, complementation group A Neighboring gene STARR-positive B cell enhancer ABC_E8971 Neighboring gene STARR-seq mESC enhancer starr_22969 Neighboring gene STARR-seq mESC enhancer starr_22970 Neighboring gene spire type actin nucleation factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2278 Neighboring gene transcription factor 25 (basic helix-loop-helix)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Aberle T, et al. Nucleic Acids Res, 2022 Feb 28. PMID 35137157, Free PMC Article
    2. Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Wong JC, et al. Genomics, 2000 Aug 1. PMID 10936049
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program.
      Title: Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin insulator sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 276
    Names
    zfp-276

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020497.2 → NP_065243.2  zinc finger protein 276

      See identical proteins and their annotated locations for NP_065243.2

      Status: VALIDATED

      Source sequence(s)
      AK028939, AK133363, BE690413
      Consensus CDS
      CCDS52699.1
      UniProtKB/Swiss-Prot
      Q3TQL7, Q3V088, Q80ZN3, Q8C912, Q8CE64, Q9ESV2
      Related
      ENSMUSP00000001092.9, ENSMUST00000001092.15
      Conserved Domains (3) summary
      smart00868
      Location:80 → 156
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:470 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:496 → 518
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123980934..123997290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531227.5 → XP_006531290.1  zinc finger protein 276 isoform X1

      Conserved Domains (3) summary
      smart00868
      Location:80 → 156
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5189
      Location:321 → 476
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:581 → 601
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_017312923.3 → XP_017168412.1  zinc finger protein 276 isoform X2

      Conserved Domains (3) summary
      smart00868
      Location:80 → 156
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5189
      Location:321 → 476
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:581 → 601
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006531229.5 → XP_006531292.1  zinc finger protein 276 isoform X4

      Conserved Domains (2) summary
      smart00868
      Location:80 → 156
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5189
      Location:321 → 476
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    4. XM_006531228.5 → XP_006531291.1  zinc finger protein 276 isoform X3

      Conserved Domains (3) summary
      smart00868
      Location:4 → 80
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5189
      Location:245 → 400
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:505 → 525
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_030243697.2 → XP_030099557.1  zinc finger protein 276 isoform X5

      Conserved Domains (2) summary
      COG5189
      Location:75 → 117
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:222 → 242
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_387763.5 RNA Sequence

      Related
      ENSMUST00000156896.8

    2. XR_001778459.3 RNA Sequence

    3. XR_003947319.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE64.3 GenPept UniProtKB/Swiss-Prot:Q8CE64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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