Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ucp3provided by MGI
Official Full Name: uncoupling protein 3 (mitochondrial, proton carrier)provided by MGI
Primary source: MGI:MGI:1099787
See related: Ensembl:ENSMUSG00000032942 AllianceGenome:MGI:1099787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UCP-3; Slc25a9
Summary: Enables oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in lipid hydroperoxide transport and proton transmembrane transport. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrial inner membrane. Is expressed in adipose tissue; heart; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 11.6), heart adult (RPKM 10.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.36 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100122198..100135639)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100472991..100486432)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
Title: Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2.
Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.
Title: Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.
Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality.
Title: Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality.
Ablation of uncoupling protein 3 affects interrelated factors leading to lipolysis and insulin resistance in visceral white adipose tissue.
Title: Ablation of uncoupling protein 3 affects interrelated factors leading to lipolysis and insulin resistance in visceral white adipose tissue.
Absence of uncoupling protein 3 at thermoneutrality influences brown adipose tissue mitochondrial functionality in mice.
Title: Absence of uncoupling protein 3 at thermoneutrality influences brown adipose tissue mitochondrial functionality in mice.
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.
Title: UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation.
The authors demonstrated that UCP3 plays a role in energy and lipid homeostasis and in preserving lean tissues by lipotoxicity, in mice that were housed at thermoneutrality.
Title: Absence of Uncoupling Protein-3 at Thermoneutrality Impacts Lipid Handling and Energy Homeostasis in Mice.
demonstrate a correlation between mitochondrial membrane potential and mitoflash magnitude in skeletal muscle fibers that is independent of UCP3, and a role for UCP3 in the control of pHlash frequency and of proton leak- and Complex I coupled-respiration in skeletal muscle fibers
Title: Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3.
Our findings, focusing on energy balance, provide a mechanistic understanding of the promising effect of early insulin initiation on lipotoxicity. Insulin, by recovering UCP3 activity, alleviated energy surfeit and potentiated AMPK-mediated lipid homeostasis in skeletal muscle cells following exposure to PA and in gastrocnemius of mice fed HFD.
Title: Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle.
Findings indicate that while heat-induced reduction in uncoupling proteins-3 improves mitochondrial efficiency in vitro, this is not translated to in vivo improvement of exercise economy at 1600 m or 4350 m.
Title: Mitochondrial efficiency and exercise economy following heat stress: a potential role of uncoupling protein 3.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

RH94827 (e-PCR)
- UniSTS:120073

Ucp3 (e-PCR), detects polymorphism
- UniSTS:144727

AI645527 (e-PCR)
- UniSTS:179614

AB010742 (e-PCR)
- UniSTS:179615

Ucp3 (e-PCR), detects polymorphism
- UniSTS:531402

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables oxidative phosphorylation uncoupler activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidative phosphorylation uncoupler activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid hydroperoxide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fenofibrate	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to superoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to superoxide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: putative mitochondrial transporter UCP3

Names: mitochondrial uncoupling protein 3; solute carrier family 25 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009464.3 → NP_033490.1 putative mitochondrial transporter UCP3

See identical proteins and their annotated locations for NP_033490.1

Status: VALIDATED

Source sequence(s)

AC117215

Consensus CDS

CCDS21497.1

UniProtKB/Swiss-Prot

O88293, P56501

UniProtKB/TrEMBL

B2RTM2

Related

ENSMUSP00000032958.8, ENSMUST00000032958.14

Conserved Domains (2) summary

PTZ00169
Location:13 → 298

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:109 → 206

Mito_carr; Mitochondrial carrier protein