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    Pkia protein kinase inhibitor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkiaprovided by MGI
    Official Full Name
    protein kinase inhibitor, alphaprovided by MGI
    Primary source
    MGI:MGI:104747
    See related
    Ensembl:ENSMUSG00000027499 AllianceGenome:MGI:104747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKIalpha
    Summary
    Enables cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 76.3), whole brain E14.5 (RPKM 43.0) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pkia in Genome Data Viewer
    Location:
    3 A1; 3 1.96 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7431695..7510426)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7366604..7445366)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41991 Neighboring gene STARR-seq mESC enhancer starr_06828 Neighboring gene STARR-seq mESC enhancer starr_06829 Neighboring gene STARR-seq mESC enhancer starr_06830 Neighboring gene STARR-seq mESC enhancer starr_06831 Neighboring gene STARR-seq mESC enhancer starr_06832 Neighboring gene STARR-seq mESC enhancer starr_06833 Neighboring gene STARR-seq mESC enhancer starr_06834 Neighboring gene predicted gene 8823 Neighboring gene STARR-seq mESC enhancer starr_06835 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 pseudogene Neighboring gene predicted gene, 23592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. Hoy JJ, et al. FASEB J, 2020 Oct. PMID 32830375, Free PMC Article
    2. Deficient gene expression in protein kinase inhibitor alpha Null mutant mice. Gangolli EA, et al. Mol Cell Biol, 2000 May. PMID 10779334, Free PMC Article
    3. Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase. Olsen SR, et al. J Biol Chem, 1991 Jun 15. PMID 1710219
    4. Reproductive function in protein kinase inhibitor-deficient mice. Belyamani M, et al. Mol Cell Biol, 2001 Jun. PMID 11359903, Free PMC Article
    5. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Kim J, et al. Structure, 2016 Mar 1. PMID 26833386, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein kinase A inhibitor proteins (PKIs) divert GPCR-Galphas-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth.
      Title: Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of cAMP/PKA signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cAMP/PKA signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor alpha
    Names
    PKI-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410515.1 → NP_001397444.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    2. NM_001410516.1 → NP_001397445.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    3. NM_001410520.1 → NP_001397449.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    4. NM_001410524.1 → NP_001397453.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    5. NM_001410525.1 → NP_001397454.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    6. NM_001410526.1 → NP_001397455.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0

    7. NM_001410527.1 → NP_001397456.1  cAMP-dependent protein kinase inhibitor alpha

      Status: VALIDATED

      Source sequence(s)
      AC123876
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0
      Related
      ENSMUSP00000141466.2, ENSMUST00000193330.2

    8. NM_008862.4 → NP_032888.1  cAMP-dependent protein kinase inhibitor alpha

      See identical proteins and their annotated locations for NP_032888.1

      Status: VALIDATED

      Source sequence(s)
      AC123876, AC132094
      Consensus CDS
      CCDS38383.1
      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0
      Related
      ENSMUSP00000028999.7, ENSMUST00000028999.12
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      7431695..7510426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162942.1 → XP_036018835.1  cAMP-dependent protein kinase inhibitor alpha isoform X2

      UniProtKB/Swiss-Prot
      P27776, P63248, Q3UTL0
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63248.2 GenPept UniProtKB/Swiss-Prot:P63248

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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