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    Ets1 E26 avian leukemia oncogene 1, 5' domain [ Mus musculus (house mouse) ]

    Gene ID: 23871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ets1provided by MGI
    Official Full Name
    E26 avian leukemia oncogene 1, 5' domainprovided by MGI
    Primary source
    MGI:MGI:95455
    See related
    Ensembl:ENSMUSG00000032035 AllianceGenome:MGI:95455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vs; p54; Tpl1; Ets-1; D230050P06
    Summary
    Enables DNA-binding transcription factor activity; DNA-binding transcription factor binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of inflammatory response and positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 75.8), spleen adult (RPKM 42.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ets1 in Genome Data Viewer
    Location:
    9 A4; 9 17.97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32547501..32669116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32636241..32757820)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32423579-32423876 Neighboring gene predicted gene, 31871 Neighboring gene STARR-positive B cell enhancer ABC_E1110 Neighboring gene predicted gene, 31928 Neighboring gene STARR-positive B cell enhancer ABC_E6722 Neighboring gene STARR-positive B cell enhancer ABC_E8853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32524850-32525033 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32548707-32548914 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32548521-32548674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32555313-32555552 Neighboring gene predicted gene 3331 Neighboring gene STARR-seq mESC enhancer starr_23738 Neighboring gene STARR-seq mESC enhancer starr_23739 Neighboring gene STARR-seq mESC enhancer starr_23740 Neighboring gene STARR-seq mESC enhancer starr_23741 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32733458-32733567 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32736269-32736505 Neighboring gene predicted gene 27162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. Luo W, et al. J Immunol, 2014 Jul 15. PMID 24929000, Free PMC Article
    2. Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms. Tai TS, et al. Cell Mol Immunol, 2020 Nov. PMID 32139882, Free PMC Article
    3. Modulation of Ets-1 expression in B lymphocytes is dependent on the antigen receptor-mediated activation signals and cell cycle status. Raghunandan R, et al. Scand J Immunol, 2013 Feb. PMID 23216019
    4. Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling. Zhan Y, et al. J Clin Invest, 2005 Sep. PMID 16138193, Free PMC Article
    5. Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. Wang D, et al. Int Immunol, 2005 Sep. PMID 16051621

    See all (263) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population.
      Title: ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population.
    2. M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
      Title: M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1.
    3. Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
      Title: Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
    4. Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
      Title: Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus.
    5. ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
      Title: ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
    6. Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
      Title: Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.
    7. ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
      Title: ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.
    8. B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
      Title: B Cell Activation Results in IKK-Dependent, but Not c-Rel- or RelA-Dependent, Decreases in Transcription of the B Cell Tolerance-Inducing Gene Ets1.
    9. GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
      Title: GATA4 Regulates Developing Endocardium Through Interaction With ETS1.
    10. Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
      Title: Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
    Submit: New GeneRIF Correction See all GeneRIFs (118)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5)  1 citation
    • Spontaneous (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18571, MGC130355

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in PML body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein C-ets-1
    Names
    avian erythroblastosis virus E26 oncogene 1
    tumor progression locus 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038642.2 → NP_001033731.1  protein C-ets-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139108
      Consensus CDS
      CCDS40572.1
      UniProtKB/TrEMBL
      E9PWI8, Q8K3Q9
      Related
      ENSMUSP00000051303.7, ENSMUST00000050797.14
      Conserved Domains (2) summary
      cd08542
      Location:51 → 138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:247 → 331
      ETS; erythroblast transformation specific domain

    2. NM_001372534.1 → NP_001359463.1  protein C-ets-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127581, AC139108
      Consensus CDS
      CCDS90530.1
      UniProtKB/TrEMBL
      A0A5F8MPR7, Q921D8
      Related
      ENSMUSP00000159086.2, ENSMUST00000238819.2
      Conserved Domains (2) summary
      cd08542
      Location:95 → 182
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:378 → 462
      ETS; erythroblast transformation specific domain

    3. NM_001372535.1 → NP_001359464.1  protein C-ets-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139108
      UniProtKB/TrEMBL
      Q8BVW8
      Conserved Domains (2) summary
      cd08542
      Location:51 → 138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:333 → 417
      ETS; erythroblast transformation specific domain

    4. NM_001372536.1 → NP_001359465.1  protein C-ets-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC139108
      UniProtKB/TrEMBL
      Q8BVW8
      Conserved Domains (2) summary
      pfam00178
      Location:270 → 348
      Ets; Ets-domain
      cl15755
      Location:51 → 68
      SAM_superfamily; SAM (Sterile alpha motif )

    5. NM_001372537.1 → NP_001359466.1  protein C-ets-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC139108
      UniProtKB/TrEMBL
      Q8K3Q9
      Conserved Domains (2) summary
      cd08542
      Location:51 → 138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:246 → 330
      ETS; erythroblast transformation specific domain

    6. NM_011808.3 → NP_035938.2  protein C-ets-1 isoform 1

      See identical proteins and their annotated locations for NP_035938.2

      Status: VALIDATED

      Source sequence(s)
      AC139108
      Consensus CDS
      CCDS22954.1
      UniProtKB/Swiss-Prot
      P27577, Q61403
      UniProtKB/TrEMBL
      Q540Q5, Q8BVW8
      Related
      ENSMUSP00000034534.6, ENSMUST00000034534.13
      Conserved Domains (2) summary
      cd08542
      Location:51 → 138
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:334 → 418
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      32547501..32669116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154929.1 → XP_036010822.1  protein C-ets-1 isoform X1

      UniProtKB/TrEMBL
      Q8K3Q9
      Conserved Domains (2) summary
      cd08542
      Location:95 → 182
      SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
      smart00413
      Location:291 → 375
      ETS; erythroblast transformation specific domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27577.2 GenPept UniProtKB/Swiss-Prot:P27577

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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