Nsg1 neuron specific gene family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nsg1provided by MGI
Official Full Name: neuron specific gene family member 1provided by MGI
Primary source: MGI:MGI:109149
See related: Ensembl:ENSMUSG00000029126 AllianceGenome:MGI:109149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p21; m234; Neep21
Summary: Predicted to enable clathrin light chain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including amyloid precursor protein metabolic process; neurotransmitter receptor transport; and receptor recycling. Located in late endosome; lateral plasma membrane; and postsynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human NSG1 (neuronal vesicle trafficking associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 286.0), cerebellum adult (RPKM 209.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B3; 5 20.21 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (38294537..38317087, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (38137193..38159743, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development.
Title: The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.
Expression of Nsg1 in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Markers

D5Dmo3 (e-PCR), detects polymorphism
- UniSTS:233991

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor cycle	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in spontaneous synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic endosome	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic endosome	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in somatodendritic compartment	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuronal vesicle trafficking-associated protein 1

Names: brain neuron cytoplasmic protein 1; neuron-enriched endosomal protein of 21 kDa; neuron-specific protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359090.1 → NP_001346019.1 neuronal vesicle trafficking-associated protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.

Source sequence(s)

AC115931

Consensus CDS

CCDS19251.1

UniProtKB/Swiss-Prot

O54717, Q3UF63, Q62092, Q922E5

UniProtKB/TrEMBL

Q8C5M2

Conserved Domains (1) summary

pfam06387
Location:1 → 180

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_001359091.1 → NP_001346020.1 neuronal vesicle trafficking-associated protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC115931

Consensus CDS

CCDS19251.1

UniProtKB/Swiss-Prot

O54717, Q3UF63, Q62092, Q922E5

UniProtKB/TrEMBL

Q8C5M2

Conserved Domains (1) summary

pfam06387
Location:1 → 180

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_001359092.1 → NP_001346021.1 neuronal vesicle trafficking-associated protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC115931

Consensus CDS

CCDS19251.1

UniProtKB/Swiss-Prot

O54717, Q3UF63, Q62092, Q922E5

UniProtKB/TrEMBL

Q8C5M2

Related

ENSMUSP00000144396.2, ENSMUST00000201363.4

Conserved Domains (1) summary

pfam06387
Location:1 → 180

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_010942.4 → NP_035072.2 neuronal vesicle trafficking-associated protein 1

See identical proteins and their annotated locations for NP_035072.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC115931, AK076451, AK148941

Consensus CDS

CCDS19251.1

UniProtKB/Swiss-Prot

O54717, Q3UF63, Q62092, Q922E5

UniProtKB/TrEMBL

Q8C5M2

Related

ENSMUSP00000031009.5, ENSMUST00000031009.8

Conserved Domains (1) summary

pfam06387
Location:1 → 180

Calcyon; D1 dopamine receptor-interacting protein (calcyon)