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    Fcsk fucose kinase [ Mus musculus (house mouse) ]

    Gene ID: 234730, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fcskprovided by MGI
    Official Full Name
    fucose kinaseprovided by MGI
    Primary source
    MGI:MGI:1916071
    See related
    Ensembl:ENSMUSG00000033703 AllianceGenome:MGI:1916071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fuk; 1110046B12Rik
    Summary
    Enables fucokinase activity. Involved in GDP-L-fucose salvage and carbohydrate phosphorylation. Predicted to be active in cytosol. Is expressed in axial skeleton and cranium. Orthologous to human FCSK (fucose kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 21.4), duodenum adult (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fcsk in Genome Data Viewer
    Location:
    8 E1; 8 57.79 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111609088..111629120, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110882456..110902488, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene STARR-positive B cell enhancer ABC_E8264 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132 Neighboring gene predicted gene, 46052

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue distribution of L-fucokinase in rodents. Miller EN, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Mar. PMID 15694600
    2. Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation. Ng BG, et al. Am J Hum Genet, 2018 Dec 6. PMID 30503518, Free PMC Article
    3. Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose. Niittymäki J, et al. Eur J Biochem, 2004 Jan. PMID 14686921
    4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning, expression and tissue distribution of murine L-fucokinase and GDP-L-fucose pyrophosphorylase
      Title: Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-L-fucose salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-L-fucose salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-L-fucose salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-L-fucose salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in carbohydrate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to dopamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-fucose kinase
    Names
    fucokinase
    mFLJ00241 protein
    NP_758487.2
    XP_006530983.1
    XP_017168235.1
    XP_030099371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172283.3 → NP_758487.2  L-fucose kinase

      See identical proteins and their annotated locations for NP_758487.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK161763, AK164340, AY223865
      Consensus CDS
      CCDS22666.1
      UniProtKB/Swiss-Prot
      Q7TMC8, Q7TSB1, Q8C7W3, Q8CI18
      Related
      ENSMUSP00000039271.7, ENSMUST00000041382.7
      Conserved Domains (3) summary
      COG2605
      Location:707 → 996
      COG2605; Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]
      pfam07959
      Location:97 → 495
      Fucokinase; L-fucokinase
      cl00160
      Location:374 → 431
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    RNA

    1. NR_052009.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC132945, AK161763, AK164340
      Related
      ENSMUST00000212971.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111609088..111629120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312746.2 → XP_017168235.1  L-fucose kinase isoform X1

      Conserved Domains (2) summary
      PRK13412
      Location:512 → 895
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:1 → 343
      Fucokinase; L-fucokinase

    2. XM_030243511.1 → XP_030099371.1  L-fucose kinase isoform X3

      Conserved Domains (2) summary
      PRK13412
      Location:212 → 595
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:2 → 43
      Fucokinase; L-fucokinase

    3. XM_006530920.2 → XP_006530983.1  L-fucose kinase isoform X2

      Conserved Domains (2) summary
      PRK13412
      Location:336 → 719
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:32 → 167
      Fucokinase; L-fucokinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMC8.1 GenPept UniProtKB/Swiss-Prot:Q7TMC8

    Gene LinkOut

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