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    Hectd2 HECT domain E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 226098, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hectd2provided by MGI
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:2442663
    See related
    Ensembl:ENSMUSG00000041180 AllianceGenome:MGI:2442663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921524L07; A630025O09Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Is expressed in brain; large intestine; lymph node; and male reproductive gland or organ. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.4), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hectd2 in Genome Data Viewer
    Location:
    19 C2; 19 31.77 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36531420..36598535)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36554126..36621135)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32143 Neighboring gene predicted gene, 41838 Neighboring gene Hectd2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_46028 Neighboring gene STARR-seq mESC enhancer starr_46029 Neighboring gene protein phosphatase 1, regulatory subunit 3C Neighboring gene predicted gene, 57662

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HECTD2 is associated with susceptibility to mouse and human prion disease. Lloyd SE, et al. PLoS Genet, 2009 Feb. PMID 19214206, Free PMC Article
    2. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Coon TA, et al. Sci Transl Med, 2015 Jul 8. PMID 26157031, Free PMC Article
    3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HECTD2
    Names
    HECT domain containing 2
    HECT domain-containing protein 2
    HECT-type E3 ubiquitin transferase HECTD2
    NP_001156943.1
    NP_766225.2
    XP_006527054.1
    XP_017173648.1
    XP_030106754.1
    XP_030106755.1
    XP_036017457.1
    XP_036017458.1
    XP_036017459.1
    XP_036017460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163471.1 → NP_001156943.1  probable E3 ubiquitin-protein ligase HECTD2 isoform 1

      See identical proteins and their annotated locations for NP_001156943.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029549, AK142777, BE864574, BP754340, CB526486
      Consensus CDS
      CCDS50425.1
      UniProtKB/TrEMBL
      B2RPZ5
      Related
      ENSMUSP00000128387.3, ENSMUST00000169036.9
      Conserved Domains (2) summary
      smart00119
      Location:439 → 772
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:416 → 773
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. NM_172637.3 → NP_766225.2  probable E3 ubiquitin-protein ligase HECTD2 isoform 2

      See identical proteins and their annotated locations for NP_766225.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AK029549, AK142777, BP754340, CB526486
      Consensus CDS
      CCDS29773.1
      UniProtKB/Swiss-Prot
      E9QK99, Q8CBQ9, Q8CDU6
      Related
      ENSMUSP00000042646.6, ENSMUST00000047247.12
      Conserved Domains (2) summary
      smart00119
      Location:438 → 771
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:415 → 772
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      36531420..36598535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526991.5 → XP_006527054.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

      Conserved Domains (1) summary
      cd00078
      Location:313 → 670
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_036161567.1 → XP_036017460.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X6

      Conserved Domains (1) summary
      cd00078
      Location:67 → 424
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_030250895.1 → XP_030106755.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

      Conserved Domains (1) summary
      cd00078
      Location:154 → 511
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    4. XM_036161564.1 → XP_036017457.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

      Conserved Domains (1) summary
      cd00078
      Location:155 → 512
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    5. XM_030250894.1 → XP_030106754.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

      Conserved Domains (1) summary
      cd00078
      Location:155 → 512
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_036161565.1 → XP_036017458.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

      Conserved Domains (1) summary
      cd00078
      Location:154 → 511
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    7. XM_036161566.1 → XP_036017459.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

      Conserved Domains (1) summary
      cd00078
      Location:68 → 425
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    8. XM_017318159.3 → XP_017173648.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

      Conserved Domains (1) summary
      cd00078
      Location:166 → 523
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RNA

    1. XR_003952783.1 RNA Sequence

      Related
      ENSMUST00000139215.8

    2. XR_003952784.1 RNA Sequence

    3. XR_004940139.1 RNA Sequence

    4. XR_001782583.2 RNA Sequence

    5. XR_004940140.1 RNA Sequence

    6. XR_003952787.1 RNA Sequence

    7. XR_003952788.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDU6.2 GenPept UniProtKB/Swiss-Prot:Q8CDU6

    Gene LinkOut

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