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    Lin52 lin-52 DREAM MuvB core complex component [ Mus musculus (house mouse) ]

    Gene ID: 217708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lin52provided by MGI
    Official Full Name
    lin-52 DREAM MuvB core complex componentprovided by MGI
    Primary source
    MGI:MGI:3045391
    See related
    Ensembl:ENSMUSG00000085793 AllianceGenome:MGI:3045391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830457H20Rik
    Summary
    Predicted to be involved in regulation of DNA-templated transcription. Predicted to be part of DRM complex. Orthologous to human LIN52 (lin-52 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.3), cerebellum adult (RPKM 4.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lin52 in Genome Data Viewer
    Location:
    12 D1; 12 39.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84497965..84593293)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84451508..84531533)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80 Neighboring gene STARR-seq mESC enhancer starr_32738 Neighboring gene STARR-seq mESC enhancer starr_32740 Neighboring gene STARR-seq mESC enhancer starr_32741 Neighboring gene visual system homeobox 2 Neighboring gene STARR-seq mESC enhancer starr_32746 Neighboring gene ATP-binding cassette, sub-family D member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-52 homolog
    Names
    lin-52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405332.1 → NP_001392261.1  protein lin-52 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402
      UniProtKB/TrEMBL
      A0A1Y7VKE7
      Related
      ENSMUSP00000152849.2, ENSMUST00000221033.2

    2. NM_001405333.1 → NP_001392262.1  protein lin-52 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402

    3. NM_001405334.1 → NP_001392263.1  protein lin-52 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402
      UniProtKB/TrEMBL
      A0A8Q0Q6C4

    4. NM_001405335.1 → NP_001392264.1  protein lin-52 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402

    5. NM_001405336.1 → NP_001392265.1  protein lin-52 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402

    6. NM_001405337.1 → NP_001392266.1  protein lin-52 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402

    7. NM_173756.5 → NP_776117.2  protein lin-52 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110564, AC120402
      Consensus CDS
      CCDS49110.1
      UniProtKB/TrEMBL
      A0A8Q0Q6C4
      Related
      ENSMUSP00000133045.3, ENSMUST00000137170.4
      Conserved Domains (1) summary
      pfam10044
      Location:14 → 107
      LIN52; Retinal tissue protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84497965..84593293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157328.1 → XP_036013221.1  protein lin-52 homolog isoform X4

      Conserved Domains (1) summary
      pfam10044
      Location:18 → 98
      LIN52; Retinal tissue protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CD94.1 GenPept UniProtKB/Swiss-Prot:Q8CD94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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