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    Upp2 uridine phosphorylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 76654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Upp2provided by MGI
    Official Full Name
    uridine phosphorylase 2provided by MGI
    Primary source
    MGI:MGI:1923904
    See related
    Ensembl:ENSMUSG00000026839 AllianceGenome:MGI:1923904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UP2; UPASE2; UDRPASE2; 1700124F02Rik
    Summary
    Enables uridine phosphorylase activity. Involved in CMP catabolic process; UMP catabolic process; and uridine catabolic process. Is active in cytosol. Is expressed in adrenal gland and gland. Orthologous to human UPP2 (uridine phosphorylase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 6.5), liver E18 (RPKM 2.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Upp2 in Genome Data Viewer
    Location:
    2 C1.1; 2 33.16 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (58456329..58685858)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58566317..58795846)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene activin A receptor, type IC Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3377 Neighboring gene predicted gene, 50616 Neighboring gene STARR-seq mESC enhancer starr_04543 Neighboring gene VISTA enhancer mm1599 Neighboring gene activin A receptor, type 1 Neighboring gene STARR-seq mESC enhancer starr_04549 Neighboring gene STARR-seq mESC enhancer starr_04550 Neighboring gene STARR-seq mESC enhancer starr_04553 Neighboring gene STARR-seq mESC enhancer starr_04555 Neighboring gene STARR-seq mESC enhancer starr_04557 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04559 Neighboring gene coiled-coil domain containing 148 Neighboring gene STARR-seq mESC enhancer starr_04561 Neighboring gene STARR-positive B cell enhancer mm9_chr2:58998596-58998897 Neighboring gene predicted gene, 54155 Neighboring gene STARR-seq mESC enhancer starr_04563 Neighboring gene plakophilin 4 Neighboring gene STARR-seq mESC enhancer starr_04569

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates. Zhao H, et al. Biochem Biophys Res Commun, 2024 Feb 12. PMID 38183795
    2. Identification of a novel human uridine phosphorylase. Johansson M. Biochem Biophys Res Commun, 2003 Jul 18. PMID 12849978
    3. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Zhang Y, et al. Mol Endocrinol, 2004 Apr. PMID 14715930
    4. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. Roosild TP, et al. J Struct Biol, 2011 Nov. PMID 21855639, Free PMC Article
    5. A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity. Mollah MB, et al. BMC Genet, 2010 Sep 23. PMID 20860848, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
      Title: Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deoxyuridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uridine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine phosphorylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dCMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in uridine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uridine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uridine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type III intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in type III intermediate filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uridine phosphorylase 2
    Names
    L-UrdPase
    liver-specific uridine phosphorylase
    NP_001276588.1
    NP_001276589.1
    NP_083968.1
    XP_006498469.1
    XP_006498470.1
    XP_006498472.1
    XP_006498473.1
    XP_011237507.1
    XP_011237508.1
    XP_011237509.1
    XP_017174811.1
    XP_030108053.1
    XP_036018568.1
    XP_036018569.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289659.1 → NP_001276588.1  uridine phosphorylase 2 isoform 1

      See identical proteins and their annotated locations for NP_001276588.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK149444, AL844163, AW112009, BY133124
      Consensus CDS
      CCDS79797.1
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q8R093
      Related
      ENSMUSP00000060437.7, ENSMUST00000059102.13
      Conserved Domains (1) summary
      cl00303
      Location:47 → 332
      PNP_UDP_1; Phosphorylase superfamily

    2. NM_001289660.1 → NP_001276589.1  uridine phosphorylase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' and 3' terminal exons, initiates translation at an alternate start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes variant 2, which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK044005, AL844163, AW123722, CJ130127
      Consensus CDS
      CCDS71055.1
      UniProtKB/TrEMBL
      A2APN2, Q8BLN7
      Related
      ENSMUSP00000071474.6, ENSMUST00000071543.12
      Conserved Domains (1) summary
      cl00303
      Location:67 → 308
      PNP_UDP_1; Phosphorylase superfamily

    3. NM_029692.3 → NP_083968.1  uridine phosphorylase 2 isoform 3

      See identical proteins and their annotated locations for NP_083968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK149444, AL844163, AW112009, BY133124
      Consensus CDS
      CCDS16051.1
      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Related
      ENSMUSP00000099816.4, ENSMUST00000102755.4
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      58456329..58685858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498407.5 → XP_006498470.1  uridine phosphorylase 2 isoform X4

      UniProtKB/TrEMBL
      Q8BLN7
      Conserved Domains (1) summary
      cd17763
      Location:75 → 349
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    2. XM_036162676.1 → XP_036018569.1  uridine phosphorylase 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    3. XM_006498406.4 → XP_006498469.1  uridine phosphorylase 2 isoform X3

      See identical proteins and their annotated locations for XP_006498469.1

      UniProtKB/TrEMBL
      Q8BLN7
      Conserved Domains (1) summary
      cd17763
      Location:91 → 365
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    4. XM_017319322.3 → XP_017174811.1  uridine phosphorylase 2 isoform X6

      Conserved Domains (1) summary
      cl00303
      Location:158 → 189
      PNP_UDP_1; Phosphorylase superfamily

    5. XM_030252193.1 → XP_030108053.1  uridine phosphorylase 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    6. XM_011239207.2 → XP_011237509.1  uridine phosphorylase 2 isoform X3

      See identical proteins and their annotated locations for XP_011237509.1

      UniProtKB/TrEMBL
      Q8BLN7
      Conserved Domains (1) summary
      cd17763
      Location:91 → 365
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    7. XM_011239205.3 → XP_011237507.1  uridine phosphorylase 2 isoform X1

      Conserved Domains (1) summary
      cd17763
      Location:166 → 399
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    8. XM_011239206.4 → XP_011237508.1  uridine phosphorylase 2 isoform X2

      Conserved Domains (1) summary
      cd17763
      Location:166 → 399
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    9. XM_036162675.1 → XP_036018568.1  uridine phosphorylase 2 isoform X5

      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    10. XM_006498409.4 → XP_006498472.1  uridine phosphorylase 2 isoform X5

      See identical proteins and their annotated locations for XP_006498472.1

      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    11. XM_006498410.5 → XP_006498473.1  uridine phosphorylase 2 isoform X5

      See identical proteins and their annotated locations for XP_006498473.1

      UniProtKB/Swiss-Prot
      Q8CGR7
      UniProtKB/TrEMBL
      A0A2R8VHC9, Q3UEN1
      Conserved Domains (1) summary
      cd17763
      Location:37 → 311
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    RNA

    1. XR_003953741.1 RNA Sequence

    2. XR_003953739.1 RNA Sequence

    3. XR_003953740.2 RNA Sequence

    4. XR_866022.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGR7.1 GenPept UniProtKB/Swiss-Prot:Q8CGR7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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