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    Msi1 musashi RNA-binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Msi1provided by MGI
    Official Full Name
    musashi RNA-binding protein 1provided by MGI
    Primary source
    MGI:MGI:107376
    See related
    Ensembl:ENSMUSG00000054256 AllianceGenome:MGI:107376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msi1h; Musahi1; m-Msi-1
    Summary
    Enables molecular condensate scaffold activity; poly(U) RNA binding activity; and protein homodimerization activity. Predicted to be involved in central nervous system development; regulation of translation; and response to hormone. Located in cytoplasm and nucleus. Is expressed in central nervous system; gonad; gut; sensory organ; and skin. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 68.1), whole brain E14.5 (RPKM 37.5) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msi1 in Genome Data Viewer
    Location:
    5 F; 5 56.09 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115567734..115593757)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115359059..115455698)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930401G09 gene Neighboring gene predicted gene 13832 Neighboring gene STARR-seq mESC enhancer starr_14119 Neighboring gene RIKEN cDNA A930005G22 gene Neighboring gene phospholipase A2, group IB, pancreas Neighboring gene STARR-seq mESC enhancer starr_14129 Neighboring gene sirtuin 4 Neighboring gene predicted gene, 42007

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Changes in Musashi-1 subcellular localization correlate with cell cycle exit during postnatal retinal development. Nickerson PE, et al. Exp Eye Res, 2011 May. PMID 21320487
    2. Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA. Iwaoka R, et al. Molecules, 2017 Jul 19. PMID 28753936, Free PMC Article
    3. Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis. O'Valle F, et al. Biomed Res Int, 2015. PMID 26064941, Free PMC Article
    4. Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival. Dobson NR, et al. Glia, 2008 Feb. PMID 18098125, Free PMC Article
    5. Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins. Chen TC, et al. Int J Mol Sci, 2020 Mar 26. PMID 32225071, Free PMC Article

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation.
      Title: The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation.
    2. Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
      Title: Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
    3. MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/beta-Catenin Signaling Pathway.
      Title: MSI1 Stabilizes MACF1 to Inhibit Apoptosis of MC3T3-E1 Cells Induced by High Glucose and Promote Osteogenic Differentiation Through Wnt/β-Catenin Signaling Pathway.
    4. Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
      Title: Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.
    5. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.
      Title: Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi.
    6. Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.
      Title: Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.
    7. The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
      Title: The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.
    8. Interplay among p21(Waf1/Cip1), MUSASHI-1 and Kruppel-like factor 4 in activation of Bmi1-Cre(ER) reserve intestinal stem cells after gamma radiation-induced injury.
      Title: Interplay among p21(Waf1/Cip1), MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-Cre(ER) reserve intestinal stem cells after gamma radiation-induced injury.
    9. Msi1 has two RNA-binding domains.
      Title: Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA.
    10. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.
      Title: Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein Musashi homolog 1
    Names
    Musashi homolog 1(Drosophila)
    musashi-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376960.1 → NP_001363889.1  RNA-binding protein Musashi homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 328
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:22 → 96
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    2. NM_001376961.1 → NP_001363890.1  RNA-binding protein Musashi homolog 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 320
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    3. NM_001376962.1 → NP_001363891.1  RNA-binding protein Musashi homolog 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 329
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:21 → 96
      RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    4. NM_001376963.1 → NP_001363892.1  RNA-binding protein Musashi homolog 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117735
      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 174
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001417504.1 → NP_001404433.1  RNA-binding protein Musashi homolog 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5
      Related
      ENSMUSP00000070415.6, ENSMUST00000067168.9

    6. NM_001417505.1 → NP_001404434.1  RNA-binding protein Musashi homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5

    7. NM_001417506.1 → NP_001404435.1  RNA-binding protein Musashi homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC117735

    8. NM_001417507.1 → NP_001404436.1  RNA-binding protein Musashi homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5

    9. NM_001417508.1 → NP_001404437.1  RNA-binding protein Musashi homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5

    10. NM_001417509.1 → NP_001404438.1  RNA-binding protein Musashi homolog 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      F8WJA5
      Related
      ENSMUSP00000144032.2, ENSMUST00000131079.8

    11. NM_001417510.1 → NP_001404439.1  RNA-binding protein Musashi homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC117735

    12. NM_001417511.1 → NP_001404440.1  RNA-binding protein Musashi homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      A0A0J9YTX9

    13. NM_001417512.1 → NP_001404441.1  RNA-binding protein Musashi homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      A0A0J9YTX9
      Related
      ENSMUSP00000143900.2, ENSMUST00000136586.6

    14. NM_001417513.1 → NP_001404442.1  RNA-binding protein Musashi homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      A0A0J9YTX9

    15. NM_001417514.1 → NP_001404443.1  RNA-binding protein Musashi homolog 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC117735
      UniProtKB/TrEMBL
      A0A0J9YTX9

    16. NM_001417515.1 → NP_001404444.1  RNA-binding protein Musashi homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC117735

    17. NM_001417516.1 → NP_001404445.1  RNA-binding protein Musashi homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC117735

    18. NM_001417517.1 → NP_001404446.1  RNA-binding protein Musashi homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC117735

    19. NM_001417518.1 → NP_001404447.1  RNA-binding protein Musashi homolog 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC117735

    20. NM_008629.2 → NP_032655.1  RNA-binding protein Musashi homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_032655.1

      Status: VALIDATED

      Source sequence(s)
      AC117735
      Consensus CDS
      CCDS19591.1
      UniProtKB/Swiss-Prot
      Q61474, Q8BNC7
      UniProtKB/TrEMBL
      F8WJA5
      Related
      ENSMUSP00000120516.2, ENSMUST00000150779.8
      Conserved Domains (3) summary
      TIGR01628
      Location:32 → 312
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:110 → 183
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
      cd12576
      Location:22 → 96
      RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115567734..115593757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530181.5 → XP_006530244.1  RNA-binding protein Musashi homolog 1 isoform X1

      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 209
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    2. XM_036164849.1 → XP_036020742.1  RNA-binding protein Musashi homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A0J9YTX9
      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 226
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12323
      Location:7 → 80
      RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

    3. XM_030254188.1 → XP_030110048.1  RNA-binding protein Musashi homolog 1 isoform X4

      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 190
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_036164850.1 → XP_036020743.1  RNA-binding protein Musashi homolog 1 isoform X4

      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 190
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_036164852.1 → XP_036020745.1  RNA-binding protein Musashi homolog 1 isoform X6

      Conserved Domains (2) summary
      TIGR01628
      Location:2 → 191
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cl17169
      Location:1 → 45
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61474.1 GenPept UniProtKB/Swiss-Prot:Q61474

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