U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tet2 tet methylcytosine dioxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 214133, updated on 10-Dec-2024

    Summary

    Official Symbol
    Tet2provided by MGI
    Official Full Name
    tet methylcytosine dioxygenase 2provided by MGI
    Primary source
    MGI:MGI:2443298
    See related
    Ensembl:ENSMUSG00000040943 AllianceGenome:MGI:2443298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ayu17-449; mKIAA1546; E130014J05Rik
    Summary
    Enables 5-methylcytosine dioxygenase activity. Involved in myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid progenitor cell differentiation; and positive regulation of gene expression, epigenetic. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; immune system; lower urogenital tract; and reproductive system. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 4.9), CNS E11.5 (RPKM 4.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tet2 in Genome Data Viewer
    Location:
    3 G3; 3 61.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133169438..133250882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133463677..133545136, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 38 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2 Neighboring gene STARR-seq mESC enhancer starr_09025 Neighboring gene STARR-seq mESC enhancer starr_09033 Neighboring gene STARR-seq mESC enhancer starr_09034 Neighboring gene STARR-positive B cell enhancer ABC_E6131 Neighboring gene STARR-seq mESC enhancer starr_09035 Neighboring gene STARR-positive B cell enhancer ABC_E3470 Neighboring gene predicted gene 49316 Neighboring gene predicted gene, 23011

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC37385

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5-methylcytosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 5-methylcytosine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 5-methylcytosine dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 5-methylcytosine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cytosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemoglobin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within liver morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression via chromosomal CpG island demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    methylcytosine dioxygenase TET2
    Names
    probable methylcytosine dioxygenase TET2
    tet oncogene 2
    tet oncogene family member 2
    NP_001035490.2
    NP_001333665.1
    XP_006501346.1
    XP_006501349.1
    XP_006501350.1
    XP_011238370.1
    XP_036018905.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040400.2NP_001035490.2  methylcytosine dioxygenase TET2 isoform 1

      See identical proteins and their annotated locations for NP_001035490.2

      Status: VALIDATED

      Source sequence(s)
      AK129389, AK153311, BE137977, BF463367, DQ079067
      Consensus CDS
      CCDS51071.1
      UniProtKB/Swiss-Prot
      Q3U5R5, Q3U633, Q3UAI0, Q4JK59, Q6ZPN2, Q8K2K3
      UniProtKB/TrEMBL
      D0VLQ5
      Related
      ENSMUSP00000096203.4, ENSMUST00000098603.8
      Conserved Domains (1) summary
      pfam12851
      Location:12031340
      Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
    2. NM_001346736.1NP_001333665.1  methylcytosine dioxygenase TET2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120398, BF463367, DQ079067
      Consensus CDS
      CCDS84675.1
      UniProtKB/TrEMBL
      A0A0G2JF55, D0VLQ5
      Related
      ENSMUSP00000143029.2, ENSMUST00000196398.5
      Conserved Domains (1) summary
      cl40427
      Location:10481373
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      133169438..133250882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501283.5XP_006501346.1  methylcytosine dioxygenase TET2 isoform X1

      See identical proteins and their annotated locations for XP_006501346.1

      UniProtKB/TrEMBL
      A0A0G2JF55, D0VLQ5
      Conserved Domains (1) summary
      cl40427
      Location:10481373
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    2. XM_006501287.5XP_006501350.1  methylcytosine dioxygenase TET2 isoform X3

      UniProtKB/TrEMBL
      D0VLQ5
      Conserved Domains (1) summary
      cl40427
      Location:10481364
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    3. XM_006501286.5XP_006501349.1  methylcytosine dioxygenase TET2 isoform X2

      UniProtKB/TrEMBL
      D0VLQ5
      Conserved Domains (1) summary
      cl40427
      Location:10481372
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    4. XM_011240068.4XP_011238370.1  methylcytosine dioxygenase TET2 isoform X1

      See identical proteins and their annotated locations for XP_011238370.1

      UniProtKB/TrEMBL
      A0A0G2JF55, D0VLQ5
      Conserved Domains (1) summary
      cl40427
      Location:10481373
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
    5. XM_036163012.1XP_036018905.1  methylcytosine dioxygenase TET2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JF55, D0VLQ5
      Conserved Domains (1) summary
      cl40427
      Location:10481373
      Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145989.1: Suppressed sequence

      Description
      NM_145989.1: This RefSeq was permanently suppressed based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.