Ntmt2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntmt2provided by MGI
Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by MGI
Primary source: MGI:MGI:2685053
See related: Ensembl:ENSMUSG00000040113 AllianceGenome:MGI:2685053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm207; NTM1B; Mettl11b
Summary: Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 71.0 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (163529415..163552801, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (163702993..163725232, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-terminal protein N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-terminal protein N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-terminal protein N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid methylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal protein amino acid methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-terminal Xaa-Pro-Lys N-methyltransferase 2

Names: X-Pro-Lys N-terminal protein methyltransferase 1B; alpha N-terminal protein methyltransferase 1B; methyltransferase like 11B; methyltransferase-like protein 11B

NP_001137428.1

EC 2.1.1.299

XP_036020749.1

EC 2.1.1.299

XP_036020757.1

EC 2.1.1.299

XP_036020760.1

EC 2.1.1.299

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143956.1 → NP_001137428.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2

See identical proteins and their annotated locations for NP_001137428.1

Status: PROVISIONAL

Source sequence(s)

BC172048

Consensus CDS

CCDS48420.1

UniProtKB/Swiss-Prot

B2RXM4

Related

ENSMUSP00000124211.2, ENSMUST00000159679.8

Conserved Domains (1) summary

cl17173
Location:63 → 277

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

163529415..163552801 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164867.1 → XP_036020760.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X3

Conserved Domains (1) summary

cl17173
Location:17 → 183

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036164856.1 → XP_036020749.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

Conserved Domains (1) summary

cl17173
Location:47 → 261

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036164864.1 → XP_036020757.1 N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X2

Conserved Domains (1) summary

cl17173
Location:2 → 212

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...